COPS4

Gene Symbol	COPS4
Entrez Gene	51138
Alt Symbol	CSN4
Species	Human
Gene Type	protein-coding
Description	COP9 signalosome subunit 4
Other Description	COP9 constitutive photomorphogenic homolog subunit 4|COP9 signalosome complex subunit 4|JAB1-containing signalosome subunit 4|SGN4|signalosome subunit 4
Swissprots	Q561W7 B3KST5 Q9BT78 Q9Y677 Q9NW31 B3KN88
Accessions	EAX05921 EAX05922 Q9BT78 AF100757 AAD43021 AK001148 BAG50860 AK001210 BAA91555 AK024005 BAG51250 AK094238 BAG52847 AK223178 BAD96898 BC004302 AAH04302 BC009292 AAH09292 BC093007 AAH93007 CD690475 JF432698 ADZ15915 XM_011532019 XP_011530321 NM_001258006 NP_001244935 NM_016129 NP_057213
Function	Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. Also involved in the deneddylation of non-cullin subunits such as STON2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1, IRF8/ICSBP and SNAPIN, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. {ECO:0000269|PubMed:11285227, ECO:0000269|PubMed:11337588, ECO:0000269|PubMed:12628923, ECO:0000269|PubMed:12732143, ECO:0000269|PubMed:21102408, ECO:0000269|PubMed:9535219}.
Subcellular Location	Cytoplasm. Nucleus. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

COPS4 / CSN4 Antibody Blocking Peptide - LS-E20697 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

COPS4 / CSN4 Antibody Blocking Peptide - LS-E20698 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

COPS4 blocking peptide - GTX24543-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog, Rat, Bovine

COPS4 Blocking Peptide - 33R-10150 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

COPS4 fusion protein - Ag0735 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human COPS4, GST-tagged - COPS4-11461H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human COP9 signalosome complex subunit 4(COPS4) - CSB-YP880098HU CSB-EP880098HU CSB-BP880098HU CSB-MP880098HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

COPS4 Protein - abx163500 from Abbexa Category Protein Species Human, Mouse, Rat

COPS4 - TP303441 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

COPS4 Recombinant Protein Antigen - NBP1-85434PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

COPS4 Peptide, Human - M34GP03501H from Creative Peptides Category Peptide Source Synthetic. Species Human

COPS4 Recombinant Protein Antigen - NBP2-55230PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E. coli Species Human

COP9 signalosome complex subunit 4 (COPS4), Recombinant Protein - MBS1409832 from MyBioSource Category Protein Prices $1,180.00, $1,180.00, $1,400.00, $1,400.00, $1,890.00, $1,890.00, $2,355.00, $2,355.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Orangutan

COP9 signalosome complex subunit 4 (COPS4), Recombinant Protein - MBS1311649 from MyBioSource Category Protein Prices $1,180.00, $1,180.00, $1,400.00, $1,400.00, $1,890.00, $1,890.00, $2,355.00, $2,355.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

COP9 signalosome complex subunit 4 (csn-4), Recombinant Protein - MBS1316279 from MyBioSource Category Protein Prices $1,220.00, $1,220.00, $1,440.00, $1,440.00, $1,975.00, $1,975.00, $2,440.00, $2,440.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Neurospora crassa

COP9 signalosome complex subunit 4 (CSN4), Recombinant Protein - MBS1185072 from MyBioSource Category Protein Prices $770.00, $770.00, $995.00, $995.00, $1,065.00, $1,065.00, $1,520.00, $1,520.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell

COP9 signalosome complex subunit 4 (csnD), Recombinant Protein - MBS1308298 from MyBioSource Category Protein Prices $1,180.00, $1,180.00, $1,400.00, $1,400.00, $1,900.00, $1,900.00, $2,360.00, $2,360.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Emericella

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