COPS4

Gene Symbol COPS4
Entrez Gene 51138
Alt Symbol CSN4
Species Human
Gene Type protein-coding
Description COP9 signalosome subunit 4
Other Description COP9 constitutive photomorphogenic homolog subunit 4|COP9 signalosome complex subunit 4|JAB1-containing signalosome subunit 4|SGN4|signalosome subunit 4
Swissprots Q561W7 B3KST5 Q9BT78 Q9Y677 Q9NW31 B3KN88
Accessions EAX05921 EAX05922 Q9BT78 AF100757 AAD43021 AK001148 BAG50860 AK001210 BAA91555 AK024005 BAG51250 AK094238 BAG52847 AK223178 BAD96898 BC004302 AAH04302 BC009292 AAH09292 BC093007 AAH93007 CD690475 JF432698 ADZ15915 XM_011532019 XP_011530321 NM_001258006 NP_001244935 NM_016129 NP_057213
Function Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. Also involved in the deneddylation of non-cullin subunits such as STON2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1, IRF8/ICSBP and SNAPIN, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. {ECO:0000269|PubMed:11285227, ECO:0000269|PubMed:11337588, ECO:0000269|PubMed:12628923, ECO:0000269|PubMed:12732143, ECO:0000269|PubMed:21102408, ECO:0000269|PubMed:9535219}.
Subcellular Location Cytoplasm. Nucleus. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle.

Anti-COPS4 antibody [EPR7453] - ab139688 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR7453
All lanes : Anti-COPS4 antibody [EPR7453] (ab139688) at 1/1000 dilutionLane 1 : SH-SY5Y cell lysateLane 2 : HepG2 cell lysateLane 3 : HeLa cell lysateLane 4 : PC3 cell lysateLysates/proteins at 10 µg per lane.SecondaryHRP labelled goat anti-rabbit at 1/2000 dilution

Anti-COPS4 / CSN4 Antibody (C-Terminus) - LS-C286956 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
Detection of Human CSN4 by Western Blot. Samples: Whole cell lysate (50 ug - E; 25 ug - T) from HEK 293T cells that were mock transfected (E) or transfected with a CSN4 expression construct (T). Antibody: Affinity purified rabbit anti-CSN4 antibody used at the indicated concentrations. Detection: Chemiluminescence with a 10 second exposure.

Anti-COPS4 / CSN4 Antibody (aa53-102) - LS-C145812 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
COPS4 antibody LS-C145812 Western blot of Rat Lung lysate. Antibody concentration 1 ug/ml.

Anti-COPS4 / CSN4 Antibody (aa143-192) - LS-C102717 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
COPS4 antibody LS-C102717 Western blot of HepG2 cell lysate.

COPS4 Antibody - NBP1-85434 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: COPS4 Antibody [NBP1-85434] - Lane 1: Marker [kDa] 230, 130, 95, 72, 56, 36, 28, 17, 11. Lane 2: Human cell line RT-4. Lane 3: Human cell line U-251MG sp

COPS4 Antibody - NBP2-15962 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: COPS4 Antibody [NBP2-15962] - Sample (30 ug of whole cell lysate) A: HCT116 10% SDS PAGE gel, diluted at 1:1000.

COPS4 Antibody - NBP2-15961 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: COPS4 Antibody [NBP2-15961] - Sample (30 ug of whole cell lysate) A: HeLa 10% SDS PAGE gel, diluted at 1:10000.

COPS4 Antibody - NBP1-56646 from Novus Biologicals

Prices $369.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western Blot: COPS4 Antibody [NBP1-56646] - HepG2 cell lysate, concentration 0.2-1 ug/ml.

COPS4 Polyclonal Antibody - bs-9123R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-COPS4 antibody produced in rabbit - SAB2103226 from Sigma-Aldrich

Prices $347.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-COPS4, antibody produced in rabbit: <B>Cat. No. SAB2103226</B>: Immunoblotting analysis of COPS4 in HepG2 cell lysate with COPS4 anitbody at 1 μg/mL.

Anti-COPS4 (386-400) antibody produced in rabbit - SAB1101285 from Sigma-Aldrich

Prices $328.50
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
<B>Immunofluorescence</B><BR/>Anti-COPS4 (386-400) (RB): <B>Cat. No. SAB1101285</B>: Immunofluorescence of HUVEC cells using COPS4 (386-400) (RB), Cat. No. SAB1101285 (red) at a 1:100 dilution, taken at 40x magnification and nuclear staining with Hoescht 33342 (blue).Yale HTCB IF procedure used. Images have been adjusted to improve viewing quality. If you would like the original image, please send a request to protocols@sial.com

Anti-COPS4 antibody produced in rabbit - HPA036894 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-COPS4: <B>Cat. No. HPA036894</B>: Immunohistochemical staining of human cerebellum shows strong nuclear and cytoplasmic positivity in Purkinje cells.

COPS4 antibody - middle region (ARP56841_P050) - ARP56841_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

cops4 antibody - zf124802 from GeneTex

Host Rabbit
Clonality Polyclonal

cops4 antibody - zf124803 from GeneTex

Host Rabbit
Clonality Polyclonal

COPS4 antibody - GTX12322 from GeneTex

Prices $289.00
Sizes 50 μg
Host Rabbit
Clonality Polyclonal

COPS4 antibody [N1C1] - GTX118165 from GeneTex

Prices $119.00
Sizes 25 μl
Host Rabbit
Clonality Polyclonal
Anti-COPS4 antibody [N1C1] used in IHC (Formalin-fixed paraffin-embedded sections). GTX118165

COPS4 antibody [N3C3] - GTX117852 from GeneTex

Prices $119.00
Sizes 25 μl
Host Rabbit
Clonality Polyclonal
Anti-COPS4 antibody [N3C3] used in ICC/IF. GTX117852

COPS4 antibody - 70R-3609 from Fitzgerald

Prices $345.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

COPS4 antibody - 70R-16515 from Fitzgerald

Prices $375.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

COPS4 antibody - 10464-1-AP from Acris Antibodies

Prices $270.00
Sizes 150 µl
Host Rabbit
Clonality Polyclonal
PC-3 cell were subjected to SDS PAGE followed by western blot with 10464-1-AP(COPS4 Antibody) at dilution of 1:800

COPS4 antibody - H00051138-B01P from Acris Antibodies

Prices $1,530.00
Sizes 500 µg
Host Mouse
Clonality Polyclonal

COPS4 Antibody - 27-100 from ProSci

Prices $315.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Antibody used in WB on Human HepG2 at 0.2-1 ug/ml.

COPS4 antibody - 10464-1-AP from Proteintech Group

Prices $279.00
Sizes con: 35 μg/150μl
Host Rabbit
Clonality Polyclonal
A2780 cells were subjected to SDS PAGE followed by western blot with 10464-1-AP(COPS4 antibody) at dilution of 1:500

COP9 constitutive photomorphogenic homolog subunit 4, Polyclonal Antibody - MBS716804 from MyBioSource

Prices $230.00, $500.00
Sizes 50 µl, 150 µl
Host Rabbit
Clonality Polyclonal
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