COPS4

Gene Symbol	COPS4
Entrez Gene	51138
Alt Symbol	CSN4
Species	Human
Gene Type	protein-coding
Description	COP9 signalosome subunit 4
Other Description	COP9 constitutive photomorphogenic homolog subunit 4|COP9 signalosome complex subunit 4|JAB1-containing signalosome subunit 4|SGN4|signalosome subunit 4
Swissprots	Q561W7 B3KST5 Q9BT78 Q9Y677 Q9NW31 B3KN88
Accessions	EAX05921 EAX05922 Q9BT78 AF100757 AAD43021 AK001148 BAG50860 AK001210 BAA91555 AK024005 BAG51250 AK094238 BAG52847 AK223178 BAD96898 BC004302 AAH04302 BC009292 AAH09292 BC093007 AAH93007 CD690475 JF432698 ADZ15915 XM_011532019 XP_011530321 NM_001258006 NP_001244935 NM_016129 NP_057213
Function	Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. Also involved in the deneddylation of non-cullin subunits such as STON2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1, IRF8/ICSBP and SNAPIN, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. {ECO:0000269|PubMed:11285227, ECO:0000269|PubMed:11337588, ECO:0000269|PubMed:12628923, ECO:0000269|PubMed:12732143, ECO:0000269|PubMed:21102408, ECO:0000269|PubMed:9535219}.
Subcellular Location	Cytoplasm. Nucleus. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

COPS4 - MBS1271808 from MyBioSource Prices $175.00 Sizes 10ug plasmid + 200ul glycerol stock Species Human Accession BC004302

Human COPS4 cDNA clone(NM_016129.2) - CDFH004086 from Creative Biomart Species Human Accession NM_016129.2

Human COPS4 cDNA clone(NM_016129.2) - CDFH004087 from Creative Biomart Species Human Accession NM_016129.2

Human COPS4 ORF Clone(NM_016129.2) - CDCR300637 from Creative Biomart Species Human Accession NM_016129.2

Human COPS4 ORF Clone(NM_016129.2) - CDCR300638 from Creative Biomart Species Human Accession NM_016129.2

Human COPS4 ORF Clone(NM_016129.2) - CDCR300639 from Creative Biomart Species Human Accession NM_016129.2

Human COPS4 ORF Clone(NM_016129.2) - CDCR300637 from Creative biogene Species Human

Human COPS4 ORF clone (NM_001258006.1) - CDCR049624 from Creative biogene Species Human

Human COPS4 ORF Clone (BC004302) - CDCS410163 from Creative biogene Species Human Accession B3KM48

Human COPS4 cDNA Clone(NM_016129.2) - CDFH004086 from Creative biogene Species Human

Human COPS4 cDNA Clone(NM_016129.2) - CDFH004087 from Creative biogene Species Human

Human COPS4 Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG16982-ACR from Sino Biological Species Human

Human COPS4 Gene ORF cDNA clone expression plasmid, N-GFPSpark tag - HG16982-ANG from Sino Biological Species Human

Human COPS4 Gene ORF cDNA clone expression plasmid, N-OFPSpark tag - HG16982-ANR from Sino Biological Species Human

Human COPS4 Gene ORF cDNA clone expression plasmid, C-His tag - HG16982-CH from Sino Biological Species Human

Human COPS4 Gene ORF cDNA clone expression plasmid, C-Myc tag - HG16982-CM from Sino Biological Species Human

Human COPS4 Gene ORF cDNA clone expression plasmid, C-HA tag - HG16982-CY from Sino Biological Species Human

Human COPS4 Gene ORF cDNA clone expression plasmid, N-Flag tag - HG16982-NF from Sino Biological Species Human

Human COPS4 Gene ORF cDNA clone expression plasmid, N-His tag - HG16982-NH from Sino Biological Species Human

Human COPS4 Gene ORF cDNA clone expression plasmid, N-HA tag - HG16982-NY from Sino Biological Species Human

Human COPS4 Gene ORF cDNA clone in cloning vector - HG16982-U from Sino Biological Species Human

Human COPS4 Gene ORF cDNA clone expression plasmid - HG16982-UT from Sino Biological Species Human

Human COPS4 Gene ORF cDNA clone expression plasmid, N-Myc tag - HG16982-NM from Sino Biological Species Human

Human COPS4 Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG16982-ACG from Sino Biological Species Human

Human COPS4 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG16982-CF from Sino Biological Species Human

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