Gene Symbol | EIF3A |
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Entrez Gene | 8661 |
Alt Symbol | EIF3, EIF3S10, P167, TIF32, eIF3-p170, eIF3-theta, p180, p185 |
Species | Human |
Gene Type | protein-coding |
Description | eukaryotic translation initiation factor 3, subunit A |
Other Description | EIF3, p180 subunit|centrosomin homolog|cytoplasmic protein p167|eIF-3-theta|eIF3 p167|eIF3 p180|eIF3 p185|eukaryotic translation initiation factor 3 subunit 10|eukaryotic translation initiation factor 3 subunit A|eukaryotic translation initiation factor 3, subunit 10 (theta, 150/170kD)|eukaryotic translation initiation factor 3, subunit 10 (theta, 170kD)|eukaryotic translation initiation factor 3, subunit 10 theta, 150/170kDa|eukaryotic translation initiation factor 3, subunit 10, 170kD |
Swissprots | Q15778 F5H335 Q14152 O00653 B1AMV5 B4DYS1 |
Accessions | AAB41586 EAW49408 Q14152 AJ227915 AK302575 BAG63833 AK307610 AK309542 AU279600 BC020285 BC033769 AAH33769 BC054342 AAH54342 BC064926 AAH64926 BC107776 AAI07777 BC114429 AAI14430 D50929 BAA09488 JX312508 AFR31791 U58046 AAB41584 U78311 AAB80695 NM_003750 NP_003741 |
Function | Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. {ECO:0000255|HAMAP- Rule:MF_03000, ECO:0000269|PubMed:11169732}. |
Subcellular Location | Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03000, ECO:0000269|PubMed:9150439}. |
Top Pathways | RNA transport |
Human EIF3A ELISA Kit (Sandwich ELISA) - LS-F11362 from LifeSpan Bioscience
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Epidermal Growth Factor Receptor 2, EGFR2, Human, ELISA Kit - E-EL-H1629 from ARP American Research Products
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Epidermal Growth Factor Receptor 2, EGFR2, Rabbit, ELISA Kit - E-EL-RB1034 from ARP American Research Products
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Epidermal Growth Factor Receptor 2, EGFR2, Chicken, ELISA Kit - E-EL-Ch1890 from ARP American Research Products
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Epidermal Growth Factor Receptor 2, EGFR2, Porcine, ELISA Kit - E-EL-P1379 from ARP American Research Products
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Epidermal Growth Factor Receptor 2, EGFR2, Monkey, ELISA Kit - E-EL-MK0362 from ARP American Research Products
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Rat EIF3A ELISA Kit (Custom ELISA) - LS-F18725 from LifeSpan Bioscience
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Mouse EIF3A ELISA Kit (Custom ELISA) - LS-F18726 from LifeSpan Bioscience
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Human Eukaryotic translation initiation factor 3 subunit A ELISA Kit - abx251306 from Abbexa
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Human Eukaryotic translation initiation factor 3 subunit A ELISA Kit - EKE53368 from Biomatik
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EIF3A ELISA Kit (Human) (OKEH01347) - OKEH01347 from Aviva Systems Biology
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Human Eukaryotic translation initiation factor 3 subunit A ELISA Kit - EK4050 from Signalway Antibody
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Eukaryotic translation initiation factor 3 subunit A, ELISA Kit - MBS9427879 from MyBioSource
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Eukaryotic translation initiation factor 3 subunit A, ELISA Kit - MBS760298 from MyBioSource
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Eukaryotic translation initiation factor 3 subunit A, ELISA Kit - MBS2887678 from MyBioSource
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Human EIF3A ELISA Kit (Sandwich ELISA) - LS-F33578 from LifeSpan Bioscience
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Mouse EIF3A ELISA Kit (Sandwich ELISA) - LS-F38312 from LifeSpan Bioscience
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Human EIF3A ELISA Kit (Sandwich ELISA) - LS-F38062 from LifeSpan Bioscience
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