| Gene Symbol |
EIF3A
|
| Entrez Gene |
8661
|
| Alt Symbol |
EIF3, EIF3S10, P167, TIF32, eIF3-p170, eIF3-theta, p180, p185
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
eukaryotic translation initiation factor 3, subunit A
|
| Other Description |
EIF3, p180 subunit|centrosomin homolog|cytoplasmic protein p167|eIF-3-theta|eIF3 p167|eIF3 p180|eIF3 p185|eukaryotic translation initiation factor 3 subunit 10|eukaryotic translation initiation factor 3 subunit A|eukaryotic translation initiation factor 3, subunit 10 (theta, 150/170kD)|eukaryotic translation initiation factor 3, subunit 10 (theta, 170kD)|eukaryotic translation initiation factor 3, subunit 10 theta, 150/170kDa|eukaryotic translation initiation factor 3, subunit 10, 170kD
|
| Swissprots |
Q15778 F5H335 Q14152 O00653 B1AMV5 B4DYS1
|
| Accessions |
AAB41586 EAW49408 Q14152 AJ227915 AK302575 BAG63833 AK307610 AK309542 AU279600 BC020285 BC033769 AAH33769 BC054342 AAH54342 BC064926 AAH64926 BC107776 AAI07777 BC114429 AAI14430 D50929 BAA09488 JX312508 AFR31791 U58046 AAB41584 U78311 AAB80695 NM_003750 NP_003741
|
| Function |
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. {ECO:0000255|HAMAP- Rule:MF_03000, ECO:0000269|PubMed:11169732}.
|
| Subcellular Location |
Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03000, ECO:0000269|PubMed:9150439}.
|
| Top Pathways |
RNA transport
|