EIF3A

Gene Symbol EIF3A
Entrez Gene 8661
Alt Symbol EIF3, EIF3S10, P167, TIF32, eIF3-p170, eIF3-theta, p180, p185
Species Human
Gene Type protein-coding
Description eukaryotic translation initiation factor 3, subunit A
Other Description EIF3, p180 subunit|centrosomin homolog|cytoplasmic protein p167|eIF-3-theta|eIF3 p167|eIF3 p180|eIF3 p185|eukaryotic translation initiation factor 3 subunit 10|eukaryotic translation initiation factor 3 subunit A|eukaryotic translation initiation factor 3, subunit 10 (theta, 150/170kD)|eukaryotic translation initiation factor 3, subunit 10 (theta, 170kD)|eukaryotic translation initiation factor 3, subunit 10 theta, 150/170kDa|eukaryotic translation initiation factor 3, subunit 10, 170kD
Swissprots Q15778 F5H335 Q14152 O00653 B1AMV5 B4DYS1
Accessions AAB41586 EAW49408 Q14152 AJ227915 AK302575 BAG63833 AK307610 AK309542 AU279600 BC020285 BC033769 AAH33769 BC054342 AAH54342 BC064926 AAH64926 BC107776 AAI07777 BC114429 AAI14430 D50929 BAA09488 JX312508 AFR31791 U58046 AAB41584 U78311 AAB80695 NM_003750 NP_003741
Function Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. {ECO:0000255|HAMAP- Rule:MF_03000, ECO:0000269|PubMed:11169732}.
Subcellular Location Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03000, ECO:0000269|PubMed:9150439}.
Top Pathways RNA transport

eIF3θ CRISPR/Cas9 KO Plasmid (h) - sc-406405 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

eIF3θ HDR Plasmid (h) - sc-406405-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

eIF3θ Double Nickase Plasmid (h) - sc-406405-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

eIF3θ Double Nickase Plasmid (h2) - sc-406405-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

eIF3θ CRISPR Activation Plasmid (h) - sc-406405-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

eIF3θ CRISPR Activation Plasmid (h2) - sc-406405-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

eIF3θ Lentiviral Activation Particles (h) - sc-406405-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

eIF3θ Lentiviral Activation Particles (h2) - sc-406405-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

eIF3θ siRNA (h) - sc-40550 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

eIF3θ shRNA Plasmid (h) - sc-40550-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

eIF3θ shRNA (h) Lentiviral Particles - sc-40550-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU029801 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN7757 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7757 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

EIF3A siRNA (Human) - CRH5696 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

EIF3A RNAi - H00008661-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

EIF3A - MBS8228485 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human EIF3A (NM_003750.2) - SHH284421 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human EIF3S10(NM_003750.2) - SHH029171 from Creative biogene

Category siRNA
Species Reactivities Human

Human EIF3A siRNA - orb266198 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

EIF3A shRNA Plasmid (Human) - CHH5696 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

EIF3A miRNA 3'UTR clone - MiUTR1H-03162 from Creative biogene

Species Reactivities Human
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