| Gene Symbol |
SIRT1
|
| Entrez Gene |
23411
|
| Alt Symbol |
SIR2L1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
sirtuin 1
|
| Other Description |
NAD-dependent deacetylase sirtuin-1|NAD-dependent protein deacetylase sirtuin-1|SIR2-like protein 1|SIR2alpha|hSIR2|hSIRT1|regulatory protein SIR2 homolog 1|sir2-like 1|sirtuin type 1
|
| Swissprots |
Q9GZR9 Q5JVQ0 Q9Y6F0 Q2XNF6 Q96EB6
|
| Accessions |
ABB72675 CAF86815 CAL00153 CAL48196 CAN36290 CAV28860 EAW54258 EAW54259 Q96EB6 AA452304 AF083106 AAD40849 AF235040 AAG38486 AK027686 BAG51365 AK074805 BAG52006 AK289743 BAF82432 AL136741 BC012499 AAH12499 BX648554 DB162635 JQ768366 AFI98394 XM_005269663 XP_005269720 XM_006717737 XP_006717800 XM_011539561 XP_011537863 NM_001142498 NP_001135970 NM_012238 NP_036370
|
| Function |
NAD-dependent protein deacetylase that links transcriptional regulation directly to intracellular energetics and participates in the coordination of several separated cellular functions such as cell cycle, response to DNA damage, metobolism, apoptosis and autophagy. Can modulate chromatin function through deacetylation of histones and can promote alterations in the methylation of histones and DNA, leading to transcriptional repression. Deacetylates a broad range of transcription factors and coregulators, thereby regulating target gene expression positively and negatively. Serves as a sensor of the cytosolic ratio of NAD(+)/NADH which is altered by glucose deprivation and metabolic changes associated with caloric restriction. Is essential in skeletal muscle cell differentiation and in response to low nutrients mediates the inhibitory effect on skeletal myoblast differentiation which also involves 5'-AMP-activated protein kinase (AMPK) and nicotinamide phosphoribosyltransferase (NAMPT).
|
| Subcellular Location |
Nucleus, PML body. Cytoplasm. Nucleus {ECO:0000269|PubMed:20955178}. Note=Recruited to the nuclear bodies via its interaction with PML. Colocalized with APEX1 in the nucleus. May be found in nucleolus, nuclear euchromatin, heterochromatin and inner membrane. Shuttles between nucleus and cytoplasm (By similarity). Colocalizes in the nucleus with XBP1 isoform 2 (PubMed:20955178). {ECO:0000250|UniProtKB:Q923E4, ECO:0000269|PubMed:20955178}.
|
| Tissue Specificity |
Widely expressed. {ECO:0000269|PubMed:10381378}.
|
| Top Pathways |
Amphetamine addiction, MicroRNAs in cancer, AMPK signaling pathway, Glucagon signaling pathway
|