SIRT1

Gene Symbol	SIRT1
Entrez Gene	23411
Alt Symbol	SIR2L1
Species	Human
Gene Type	protein-coding
Description	sirtuin 1
Other Description	NAD-dependent deacetylase sirtuin-1|NAD-dependent protein deacetylase sirtuin-1|SIR2-like protein 1|SIR2alpha|hSIR2|hSIRT1|regulatory protein SIR2 homolog 1|sir2-like 1|sirtuin type 1
Swissprots	Q9GZR9 Q5JVQ0 Q9Y6F0 Q2XNF6 Q96EB6
Accessions	ABB72675 CAF86815 CAL00153 CAL48196 CAN36290 CAV28860 EAW54258 EAW54259 Q96EB6 AA452304 AF083106 AAD40849 AF235040 AAG38486 AK027686 BAG51365 AK074805 BAG52006 AK289743 BAF82432 AL136741 BC012499 AAH12499 BX648554 DB162635 JQ768366 AFI98394 XM_005269663 XP_005269720 XM_006717737 XP_006717800 XM_011539561 XP_011537863 NM_001142498 NP_001135970 NM_012238 NP_036370
Function	NAD-dependent protein deacetylase that links transcriptional regulation directly to intracellular energetics and participates in the coordination of several separated cellular functions such as cell cycle, response to DNA damage, metobolism, apoptosis and autophagy. Can modulate chromatin function through deacetylation of histones and can promote alterations in the methylation of histones and DNA, leading to transcriptional repression. Deacetylates a broad range of transcription factors and coregulators, thereby regulating target gene expression positively and negatively. Serves as a sensor of the cytosolic ratio of NAD(+)/NADH which is altered by glucose deprivation and metabolic changes associated with caloric restriction. Is essential in skeletal muscle cell differentiation and in response to low nutrients mediates the inhibitory effect on skeletal myoblast differentiation which also involves 5'-AMP-activated protein kinase (AMPK) and nicotinamide phosphoribosyltransferase (NAMPT).
Subcellular Location	Nucleus, PML body. Cytoplasm. Nucleus {ECO:0000269|PubMed:20955178}. Note=Recruited to the nuclear bodies via its interaction with PML. Colocalized with APEX1 in the nucleus. May be found in nucleolus, nuclear euchromatin, heterochromatin and inner membrane. Shuttles between nucleus and cytoplasm (By similarity). Colocalizes in the nucleus with XBP1 isoform 2 (PubMed:20955178). {ECO:0000250|UniProtKB:Q923E4, ECO:0000269|PubMed:20955178}.
Tissue Specificity	Widely expressed. {ECO:0000269|PubMed:10381378}.
Top Pathways	Amphetamine addiction, MicroRNAs in cancer, AMPK signaling pathway, Glucagon signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human SIRT1 full length protein - ab187228 from Abcam Category Protein Prices $745.00 Sizes 50 µg Source E. coli Species Human

Active human SIRT1 protein fragment - ab101130 from Abcam Category Protein Prices $302.00, $410.00 Sizes 5 µg, 10 µg Source Baculovirus infected sf9 cells Species Human

Active human SIRT1 protein fragment - ab109037 from Abcam Category Protein Prices $302.00 Sizes 10 µg Source E. coli Species Human

Active human SIRT1 protein fragment - ab54334 from Abcam Category Protein Prices $460.00 Sizes 100 µg Source E. coli Species Human

Human SIRT1 protein fragment - ab180344 from Abcam Category Protein Source E. coli Species Human

Mouse SIRT1 full length protein - ab109062 from Abcam Category Protein Source E. coli Species Mouse

Mouse SIRT1 peptide - ab28308 from Abcam Category Peptide

SIRT1 peptide - ab7770 from Abcam Category Peptide

SIRT1 peptide - ab126323 from Abcam Category Peptide

SIRT1 / Sirtuin 1 Antibody Blocking Peptide - LS-E27648 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SIRT1 / Sirtuin 1 Antibody Blocking Peptide - LS-E30932 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

SIRT1 / Sirtuin 1 Antibody Blocking Peptide - LS-E11337 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human Sirtuin 1/SIRT1 Protein - H00023411-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Source Wheat Germ Species Human

Sirtuin 1/SIRT1 Blocking Peptide - NBP1-77167PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

SIRT1-Antibody-Center-Blocking-Peptide - BP6240c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

SIRT1 blocking peptide - GTX89248-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog, Rat

SIRT1 Peptide - GTX85106-PEP from GeneTex Category Peptide Prices $149.00 Sizes 50 μg Species Human

Recombinant Human Sirtuin 1/SIRT1, CF - 7714-DA-050 from R&D Systems Category Protein Source E. coli-derived, Met1-Ser747, with a C-terminal 6-His tag.

Sirtuin 1 enzyme - orb108391 from Biorbyt Category Protein Prices $553.00 Sizes 100 μg Source E.coli Species Human

SIRT1 protein (His tag) - 80R-3758 from Fitzgerald Category Protein Prices $275.00 Sizes 100 µg Source E.coli

Human Sirtuin 1 Protein - abx069099 from Abbexa Category Protein Source E.coli Species Human

SIRT1 Peptide - AC21-2466-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

SIRT1 Peptide - AC21-2804-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

SIRT1 (254-495, His-tag) - AR51445PU-N from Acris Antibodies Category Protein Prices $790.00 Sizes 500 µg Source E. coli Species Human

SIRT1 (254-495, His-tag) - AR51445PU-S from Acris Antibodies Category Protein Prices $340.00 Sizes 100 µg Source E. coli Species Human

Search more