SIRT1

Gene Symbol	SIRT1
Entrez Gene	23411
Alt Symbol	SIR2L1
Species	Human
Gene Type	protein-coding
Description	sirtuin 1
Other Description	NAD-dependent deacetylase sirtuin-1|NAD-dependent protein deacetylase sirtuin-1|SIR2-like protein 1|SIR2alpha|hSIR2|hSIRT1|regulatory protein SIR2 homolog 1|sir2-like 1|sirtuin type 1
Swissprots	Q9GZR9 Q5JVQ0 Q9Y6F0 Q2XNF6 Q96EB6
Accessions	ABB72675 CAF86815 CAL00153 CAL48196 CAN36290 CAV28860 EAW54258 EAW54259 Q96EB6 AA452304 AF083106 AAD40849 AF235040 AAG38486 AK027686 BAG51365 AK074805 BAG52006 AK289743 BAF82432 AL136741 BC012499 AAH12499 BX648554 DB162635 JQ768366 AFI98394 XM_005269663 XP_005269720 XM_006717737 XP_006717800 XM_011539561 XP_011537863 NM_001142498 NP_001135970 NM_012238 NP_036370
Function	NAD-dependent protein deacetylase that links transcriptional regulation directly to intracellular energetics and participates in the coordination of several separated cellular functions such as cell cycle, response to DNA damage, metobolism, apoptosis and autophagy. Can modulate chromatin function through deacetylation of histones and can promote alterations in the methylation of histones and DNA, leading to transcriptional repression. Deacetylates a broad range of transcription factors and coregulators, thereby regulating target gene expression positively and negatively. Serves as a sensor of the cytosolic ratio of NAD(+)/NADH which is altered by glucose deprivation and metabolic changes associated with caloric restriction. Is essential in skeletal muscle cell differentiation and in response to low nutrients mediates the inhibitory effect on skeletal myoblast differentiation which also involves 5'-AMP-activated protein kinase (AMPK) and nicotinamide phosphoribosyltransferase (NAMPT).
Subcellular Location	Nucleus, PML body. Cytoplasm. Nucleus {ECO:0000269|PubMed:20955178}. Note=Recruited to the nuclear bodies via its interaction with PML. Colocalized with APEX1 in the nucleus. May be found in nucleolus, nuclear euchromatin, heterochromatin and inner membrane. Shuttles between nucleus and cytoplasm (By similarity). Colocalizes in the nucleus with XBP1 isoform 2 (PubMed:20955178). {ECO:0000250|UniProtKB:Q923E4, ECO:0000269|PubMed:20955178}.
Tissue Specificity	Widely expressed. {ECO:0000269|PubMed:10381378}.
Top Pathways	Amphetamine addiction, MicroRNAs in cancer, AMPK signaling pathway, Glucagon signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SIRT1 Human ELISA Kit - ab123457 from Abcam Category ELISA Kit Sensitivity 8 ng/ml Range Sample specific recoverySample typeAverage %RangeSerum10698% - 112%

SIRT1 Human SimpleStep ELISA™ Kit - ab171573 from Abcam Category ELISA Kit Prices $484.00 Sizes 1 x 96 tests Sensitivity 132 pg/ml Range 630 pg/ml - 40000 pg/ml

SIRT1 pSer47 Human ELISA Kit - ab135392 from Abcam Category ELISA Kit Prices $448.00 Sizes 1 x 96 tests Sensitivity 2 µg/ml Range 2 µg/ml - 1000 µg/ml

SIRT1 Total and pSer47 Human In-Cell ELISA Kit (Colorimetric) - ab136807 from Abcam Category ELISA Kit Prices $438.00 Sizes 1 x 96 tests Range 6000 cells/well - 100000 cells/well

SIRT1 Total and pSer47 Human In-Cell ELISA Kit (Fluorescent) - ab136808 from Abcam Category ELISA Kit Prices $438.00 Sizes 1 x 96 tests Range 3000 cells/well - 50000 cells/well

SIRT1 Total and pSer47 Human In-Cell ELISA Kit (IR) - ab135394 from Abcam Category ELISA Kit Prices $438.00 Sizes 1 x 96 tests Sensitivity > 3000 cells/well Range 3000 cells/well - 50000 cells/well

SIRT1 Activity Assay Kit (Fluorometric) - ab156065 from Abcam Category Cellular Assay Prices $464.00 Sizes 100 tests

Universal SIRT Activity Assay Kit (Colorimetric) - ab156915 from Abcam Category Cellular Assay Prices $288.00, $484.00 Sizes 48 tests, 96 tests Sensitivity > 1 ng Range 500 ng - 20000 ng

Human SIRT1 / Sirtuin 1 ELISA Kit (Sandwich ELISA) - LS-F6780 from LifeSpan Bioscience Category ELISA Kit Prices $720.00 Sizes 1 plate Sensitivity 0.31 ng/ml Range 0.781-50 ng/ml

Rat SIRT1 / Sirtuin 1 ELISA Kit (Sandwich ELISA) - LS-F6966 from LifeSpan Bioscience Category ELISA Kit Prices $780.00 Sizes 1 plate Sensitivity 0.124 ng/ml Range 0.781-50 ng/ml

Mouse SIRT1 / Sirtuin 1 ELISA Kit (Sandwich ELISA) - LS-F7496 from LifeSpan Bioscience Category ELISA Kit Prices $740.00 Sizes 1 plate Sensitivity 0.067 ng/ml Range 0.781-50 ng/ml

Human SIRT1 / Sirtuin 1 ELISA Kit (Sandwich ELISA) - LS-F12606 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 78 Range 0.781-50 ng/ml

Mouse SIRT1 / Sirtuin 1 ELISA Kit (Sandwich ELISA) - LS-F12607 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 31.2 Range 0.781-50 ng/ml

Sirtuin 1/SIRT1 Fluorometric Assay Kit - KA1367 from Novus Biologicals Category Assay Kit Prices $519.00 Sizes 1 kit

Sirtuin 1/SIRT1 Fluorometric Assay Kit - KA1366 from Novus Biologicals Category Assay Kit Prices $519.00 Sizes 1 kit

Rabbit anti-Sirt1 Antibody, Affinity Purified - PLA0132 from Sigma-Aldrich Prices $323.50 Sizes 100 µl

Sirtuin 1 ELISA Kit - 55R-1430 from Fitzgerald Category ELISA Kit Prices $895.00 Sizes 100 assays

Sirtuin 1, SIRT1, Human, ELISA Kit - E-EL-H1546 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t Sensitivity 0.188 Range 0.313-20ng/mL

NAD-dependent deacetylase sirtuin-1 (SIRT1/SIR2L1), Human, ELISA Kit - CSB-E15058h from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t Sensitivity 0.04 ng/ml Range 0.156 ng/ml-10 ng/ml

Sirtuin 1 (SIRT1), Human, ELISA Kit - SEE912Hu from ARP American Research Products Category ELISA Kit Prices $720.00 Sizes 96 t Sensitivity 0.28ng/mL Range 0.78-50ng/mL

SIRT1 Direct Fluorescent Screening Assay Kit - KA1366 from Acris Antibodies Category ELISA Kit Prices $470.00 Sizes 1 kit

SIRT1 FRET-Based Screening Assay Kit - KA1367 from Acris Antibodies Category ELISA Kit Prices $470.00 Sizes 1 kit

Human Sirtuin 1 ELISA Kit - 68ELH-Sirtuin1 from RayBiotech Category ELISA Kit

SIRT1, ELISA Kit - MBS2516070 from MyBioSource Category ELISA Kit Prices $410.00, $490.00, $2,040.00, $3,590.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.094ng/mL Range 0.156-10ng/mL

SIRT1, ELISA Kit - MBS2503120 from MyBioSource Category ELISA Kit Prices $410.00, $490.00, $2,040.00, $3,590.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity The minimum detectable dose of Human SIRT1 is 0.188ng/mL (The sensitivity of this assay, or lowest detectable limit (LDL) was defined as the lowest protein concentration that could be differentiated from zero). Range 0.313-20ng/mL

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