SIRT1

Gene Symbol	SIRT1
Entrez Gene	23411
Alt Symbol	SIR2L1
Species	Human
Gene Type	protein-coding
Description	sirtuin 1
Other Description	NAD-dependent deacetylase sirtuin-1|NAD-dependent protein deacetylase sirtuin-1|SIR2-like protein 1|SIR2alpha|hSIR2|hSIRT1|regulatory protein SIR2 homolog 1|sir2-like 1|sirtuin type 1
Swissprots	Q9GZR9 Q5JVQ0 Q9Y6F0 Q2XNF6 Q96EB6
Accessions	ABB72675 CAF86815 CAL00153 CAL48196 CAN36290 CAV28860 EAW54258 EAW54259 Q96EB6 AA452304 AF083106 AAD40849 AF235040 AAG38486 AK027686 BAG51365 AK074805 BAG52006 AK289743 BAF82432 AL136741 BC012499 AAH12499 BX648554 DB162635 JQ768366 AFI98394 XM_005269663 XP_005269720 XM_006717737 XP_006717800 XM_011539561 XP_011537863 NM_001142498 NP_001135970 NM_012238 NP_036370
Function	NAD-dependent protein deacetylase that links transcriptional regulation directly to intracellular energetics and participates in the coordination of several separated cellular functions such as cell cycle, response to DNA damage, metobolism, apoptosis and autophagy. Can modulate chromatin function through deacetylation of histones and can promote alterations in the methylation of histones and DNA, leading to transcriptional repression. Deacetylates a broad range of transcription factors and coregulators, thereby regulating target gene expression positively and negatively. Serves as a sensor of the cytosolic ratio of NAD(+)/NADH which is altered by glucose deprivation and metabolic changes associated with caloric restriction. Is essential in skeletal muscle cell differentiation and in response to low nutrients mediates the inhibitory effect on skeletal myoblast differentiation which also involves 5'-AMP-activated protein kinase (AMPK) and nicotinamide phosphoribosyltransferase (NAMPT).
Subcellular Location	Nucleus, PML body. Cytoplasm. Nucleus {ECO:0000269|PubMed:20955178}. Note=Recruited to the nuclear bodies via its interaction with PML. Colocalized with APEX1 in the nucleus. May be found in nucleolus, nuclear euchromatin, heterochromatin and inner membrane. Shuttles between nucleus and cytoplasm (By similarity). Colocalizes in the nucleus with XBP1 isoform 2 (PubMed:20955178). {ECO:0000250|UniProtKB:Q923E4, ECO:0000269|PubMed:20955178}.
Tissue Specificity	Widely expressed. {ECO:0000269|PubMed:10381378}.
Top Pathways	Amphetamine addiction, MicroRNAs in cancer, AMPK signaling pathway, Glucagon signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SignalSilence ® SirT1 siRNA I - 12241 from Cell Signaling Technology Category siRNA Prices $256.00 Sizes 300 µl (3 nmol) Species Reactivities Human

SIRT1 CRISPR/Cas9 KO Plasmid (h) - sc-400085 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

SIRT1 HDR Plasmid (h) - sc-400085-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

SIRT1 Double Nickase Plasmid (h) - sc-400085-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

SIRT1 Double Nickase Plasmid (h2) - sc-400085-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

SIRT1 CRISPR Activation Plasmid (h) - sc-400085-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

SIRT1 CRISPR Activation Plasmid (h2) - sc-400085-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

SIRT1 Lentiviral Activation Particles (h) - sc-400085-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

SIRT1 Lentiviral Activation Particles (h2) - sc-400085-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

SIRT1 siRNA (h) - sc-40986 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

SIRT1 shRNA Plasmid (h) - sc-40986-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

SIRT1 shRNA (h) Lentiviral Particles - sc-40986-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Sirtuin 1/SIRT1 RNAi - H00023411-R01 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

CompoZr® Knockout ZFN Kit - CKOZFN19359 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19359 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

SIRT1 siRNA (Human) - CRH8250 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

SIRT1 - MBS8210369 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human SIRT1 (NM_012238.4) - SHH407728 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human SIRT1(NM_001142498.1) - SHR226482 from Creative biogene Category siRNA Species Reactivities Human

SIRT1 shRNA Plasmid (Human) - CHH8250 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

SIRT1 miRNA 3'UTR clone - MiUTR1H-09412 from Creative biogene Species Reactivities Human

SIRT1 miRNA 3'UTR clone - MiUTR3H-06840 from Creative biogene Species Reactivities Human

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