COASY

Gene Symbol	COASY
Entrez Gene	80347
Alt Symbol	DPCK, NBIA6, NBP, PPAT, UKR1, pOV-2
Species	Human
Gene Type	protein-coding
Description	CoA synthase
Other Description	bifunctional coenzyme A synthase|bifunctional phosphopantetheine adenylyl transferase/dephospho CoA kinase|nucleotide binding protein|phosphopantetheine adenylyltransferase / dephosphocoenzyme A kinase
Swissprots	Q9NRM3 Q8WXD4 Q8NEW1 B2RA78 B4DLU0 Q8NBM7 Q6GS23 Q13057
Accessions	EAW60838 EAW60839 EAW60840 Q13057 AF208536 AAF87955 AF453478 AAL50813 AK075415 AK092498 AK225485 AK297153 BAG59652 AK303766 BAG64732 AK314076 BAG36775 AL360167 AL360168 AL583142 AL833588 AY094602 AAM19996 BC006354 AAH06354 BC020985 AAH20985 BC067254 AAH67254 BM473635 BM781531 BT007168 AAP35832 DA131866 DA786254 JF432607 ADZ15824 U18919 AAA69699 XM_006722116 XP_006722179 XM_011525300 XP_011523602 XM_011525301 XP_011523603 XR_429926 NM_001042529 NP_001035994 NM_001042532 NP_001035997 NM_025233 NP_079509 NM_001042530 NM_001042531
Function	Bifunctional enzyme that catalyzes the fourth and fifth sequential steps of CoA biosynthetic pathway. The fourth reaction is catalyzed by the phosphopantetheine adenylyltransferase, coded by the coaD domain; the fifth reaction is catalyzed by the dephospho-CoA kinase, coded by the coaE domain. May act as a point of CoA biosynthesis regulation. {ECO:0000269|PubMed:11923312}.
Subcellular Location	Cytoplasm {ECO:0000250}. Mitochondrion matrix {ECO:0000269|PubMed:24360804}. Note=The protein is mainly present in the mitochondrial matrix, probably anchored to the inner mitochondrial membrane, but is also present in cell lysate.
Tissue Specificity	Expressed in all tissues examined including brain, heart, skeletal muscle, colon, thymus, spleen, kidney, liver, small intestine, placenta, lung and peripheral blood leukocyte. Lowest expression in peripheral blood leukocytes and highest in kidney and liver. Isoform 2 is expressed mainly in the brain. {ECO:0000269|PubMed:11923312}.
Top Pathways	Pantothenate and CoA biosynthesis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

COASY (E-7) - sc-393812 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

COASY (E-12) - sc-107495 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

COASY (H-300) - sc-366987 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

COASY (SS06) - sc-100474 from Santa Cruz Biotechnology Prices $295.00 Sizes 100 µg/ml Host Mouse Clonality Monoclonal

Anti-COASY (phospho S182) antibody - ab45994 from Abcam Prices $370.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-COASY antibody - ab155551 from Abcam Prices $370.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-COASY antibody - ab57833 from Abcam Prices $370.00 Sizes 100 µg Host Mouse Clonality Monoclonal

Anti-COASY antibody [EPR8246] - ab129012 from Abcam Prices $313.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR8246

Anti-COASY antibody - C-terminal - ab136330 from Abcam Prices $370.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-COASY Antibody (clone 3B3) - LS-C173207 from LifeSpan Bioscience Prices $350.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 3B3

Anti-COASY Antibody (aa1-249, clone 10B2276, Azide-free) - LS-C183523 from LifeSpan Bioscience Host Mouse Clonality Monoclonal Clone 10B2276

Anti-COASY Antibody - LS-C307018 from LifeSpan Bioscience Prices $455.00 Sizes 50 µg Host Mouse Clonality Polyclonal

Anti-COASY Antibody (clone 2A12) - LS-C105180 from LifeSpan Bioscience Prices $355.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 2A12

Anti-COASY Antibody - LS-C307019 from LifeSpan Bioscience Prices $455.00 Sizes 100 µg Host Mouse Clonality Monoclonal

Anti-COASY Antibody - LS-C309949 from LifeSpan Bioscience Prices $475.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-COASY Antibody - LS-C309951 from LifeSpan Bioscience Prices $475.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-COASY Antibody (aa319-368) - LS-C169794 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-COASY Antibody (C-Terminus, clone EPR8246) - LS-C154436 from LifeSpan Bioscience Prices $395.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR8246

Anti-COASY Antibody - LS-C340910 from LifeSpan Bioscience Prices $385.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-COASY Antibody (clone 3D5) - LS-C337392 from LifeSpan Bioscience Prices $325.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 3D5

Anti-COASY Antibody (clone 2H1) - LS-C173206 from LifeSpan Bioscience Prices $325.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 2H1

COASY Antibody (3B3) - NBP2-01081 from Novus Biologicals Prices $529.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 3B3

COASY Antibody - NBP1-32649 from Novus Biologicals Prices $329.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

COASY Antibody - NBP2-15934 from Novus Biologicals Prices $329.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

COASY Antibody (2A12) - H00080347-M05 from Novus Biologicals Prices $359.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 2A12

Search more