COASY

Gene Symbol	COASY
Entrez Gene	80347
Alt Symbol	DPCK, NBIA6, NBP, PPAT, UKR1, pOV-2
Species	Human
Gene Type	protein-coding
Description	CoA synthase
Other Description	bifunctional coenzyme A synthase|bifunctional phosphopantetheine adenylyl transferase/dephospho CoA kinase|nucleotide binding protein|phosphopantetheine adenylyltransferase / dephosphocoenzyme A kinase
Swissprots	Q9NRM3 Q8WXD4 Q8NEW1 B2RA78 B4DLU0 Q8NBM7 Q6GS23 Q13057
Accessions	EAW60838 EAW60839 EAW60840 Q13057 AF208536 AAF87955 AF453478 AAL50813 AK075415 AK092498 AK225485 AK297153 BAG59652 AK303766 BAG64732 AK314076 BAG36775 AL360167 AL360168 AL583142 AL833588 AY094602 AAM19996 BC006354 AAH06354 BC020985 AAH20985 BC067254 AAH67254 BM473635 BM781531 BT007168 AAP35832 DA131866 DA786254 JF432607 ADZ15824 U18919 AAA69699 XM_006722116 XP_006722179 XM_011525300 XP_011523602 XM_011525301 XP_011523603 XR_429926 NM_001042529 NP_001035994 NM_001042532 NP_001035997 NM_025233 NP_079509 NM_001042530 NM_001042531
Function	Bifunctional enzyme that catalyzes the fourth and fifth sequential steps of CoA biosynthetic pathway. The fourth reaction is catalyzed by the phosphopantetheine adenylyltransferase, coded by the coaD domain; the fifth reaction is catalyzed by the dephospho-CoA kinase, coded by the coaE domain. May act as a point of CoA biosynthesis regulation. {ECO:0000269|PubMed:11923312}.
Subcellular Location	Cytoplasm {ECO:0000250}. Mitochondrion matrix {ECO:0000269|PubMed:24360804}. Note=The protein is mainly present in the mitochondrial matrix, probably anchored to the inner mitochondrial membrane, but is also present in cell lysate.
Tissue Specificity	Expressed in all tissues examined including brain, heart, skeletal muscle, colon, thymus, spleen, kidney, liver, small intestine, placenta, lung and peripheral blood leukocyte. Lowest expression in peripheral blood leukocytes and highest in kidney and liver. Isoform 2 is expressed mainly in the brain. {ECO:0000269|PubMed:11923312}.
Top Pathways	Pantothenate and CoA biosynthesis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

COASY-Over-expression-Lysate - LYLR4442a from Abgent, a WuXi AppTec company Category Cell Lysate Prices $325.00 Sizes 100 µg

COASY-Over-expression-Lysate - LYLR4165a from Abgent, a WuXi AppTec company Category Cell Lysate Prices $325.00 Sizes 100 µg

COASY 293T Cell Transient Overexpression Lysate(Denatured) - H00080347-T01 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

COASY overexpression lysate - LY403068 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

COASY overexpression lysate - LY420963 from Acris Antibodies Category Cell Lysate Prices $480.00 Sizes 100 µg

COASY overexpression lysate - LY425766 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

COASY 293 Cell Lysate - 402672 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

COASY Overexpression Lysate (Denatured) - H00080347-T01 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

COASY Overexpression Lysate (Native) - NBL1-09341 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

COASY Overexpression Lysate (Native) - NBL1-09340 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

COASY Overexpression Lysate (Native) - NBP2-08384 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

COASY Overexpression Lysate (Native) - NBP2-08383 from Novus Biologicals Category Cell Lysate Prices $529.00 Sizes 100 µg

COASY Overexpression Lysate (Native) - NBP2-09241 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

COASY Overexpression Lysate (Native) - NBP2-09240 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

COASY (h2): 293T Lysate - sc-117292 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

COASY Over-expression Lysate Product - GWB-45E147 from Genway Biotech Category Cell Lysate Prices $445.00 Sizes 100 µg Species Human

COASY Over-expression Lysate Product - GWB-1BE51B from Genway Biotech Category Cell Lysate Prices $445.00 Sizes 100 µg Species Human

Panoply™ Human COASY Knockdown Stable Cell Line - CSC-DC003418 from Creative biogene Category Cell Line Species Human

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