| Gene Symbol | COASY |
|---|---|
| Entrez Gene | 80347 |
| Alt Symbol | DPCK, NBIA6, NBP, PPAT, UKR1, pOV-2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | CoA synthase |
| Other Description | bifunctional coenzyme A synthase|bifunctional phosphopantetheine adenylyl transferase/dephospho CoA kinase|nucleotide binding protein|phosphopantetheine adenylyltransferase / dephosphocoenzyme A kinase |
| Swissprots | Q9NRM3 Q8WXD4 Q8NEW1 B2RA78 B4DLU0 Q8NBM7 Q6GS23 Q13057 |
| Accessions | EAW60838 EAW60839 EAW60840 Q13057 AF208536 AAF87955 AF453478 AAL50813 AK075415 AK092498 AK225485 AK297153 BAG59652 AK303766 BAG64732 AK314076 BAG36775 AL360167 AL360168 AL583142 AL833588 AY094602 AAM19996 BC006354 AAH06354 BC020985 AAH20985 BC067254 AAH67254 BM473635 BM781531 BT007168 AAP35832 DA131866 DA786254 JF432607 ADZ15824 U18919 AAA69699 XM_006722116 XP_006722179 XM_011525300 XP_011523602 XM_011525301 XP_011523603 XR_429926 NM_001042529 NP_001035994 NM_001042532 NP_001035997 NM_025233 NP_079509 NM_001042530 NM_001042531 |
| Function | Bifunctional enzyme that catalyzes the fourth and fifth sequential steps of CoA biosynthetic pathway. The fourth reaction is catalyzed by the phosphopantetheine adenylyltransferase, coded by the coaD domain; the fifth reaction is catalyzed by the dephospho-CoA kinase, coded by the coaE domain. May act as a point of CoA biosynthesis regulation. {ECO:0000269|PubMed:11923312}. |
| Subcellular Location | Cytoplasm {ECO:0000250}. Mitochondrion matrix {ECO:0000269|PubMed:24360804}. Note=The protein is mainly present in the mitochondrial matrix, probably anchored to the inner mitochondrial membrane, but is also present in cell lysate. |
| Tissue Specificity | Expressed in all tissues examined including brain, heart, skeletal muscle, colon, thymus, spleen, kidney, liver, small intestine, placenta, lung and peripheral blood leukocyte. Lowest expression in peripheral blood leukocytes and highest in kidney and liver. Isoform 2 is expressed mainly in the brain. {ECO:0000269|PubMed:11923312}. |
| Top Pathways | Pantothenate and CoA biosynthesis |
Bifunctional coenzyme A synthase (COASY), Human, ELISA Kit - E01B0888 from ARP American Research Products
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COASY (Human) Matched Antibody Pair - H00080347-AP11 from Acris Antibodies
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COASY (Human) Matched Antibody Pair - H00080347-AP22 from Acris Antibodies
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Bifunctional coenzyme A synthase (COASY), ELISA Kit - MBS7207432 from MyBioSource
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Bifunctional coenzyme A synthase (COASY), ELISA Kit - MBS7214863 from MyBioSource
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Bifunctional coenzyme A synthase (COASY), ELISA Kit - MBS7208790 from MyBioSource
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Bifunctional coenzyme A synthase (COASY), ELISA Kit - MBS7241056 from MyBioSource
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Bifunctional coenzyme A synthase (COASY), ELISA Kit - MBS7209063 from MyBioSource
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Bifunctional coenzyme A synthase (COASY), ELISA Kit - MBS7219880 from MyBioSource
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Bifunctional coenzyme A synthase (COASY), ELISA Kit - MBS7228857 from MyBioSource
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Bifunctional coenzyme A synthase (COASY), ELISA Kit - MBS7244990 from MyBioSource
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Bifunctional coenzyme A synthase (COASY), ELISA Kit - MBS7239616 from MyBioSource
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Bifunctional coenzyme A synthase (COASY), ELISA Kit - MBS7236815 from MyBioSource
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Bifunctional coenzyme A synthase (COASY), ELISA Kit - MBS7236566 from MyBioSource
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Bifunctional coenzyme A synthase (COASY), ELISA Kit - MBS7219448 from MyBioSource
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Human COASY ELISA Kit - E004942 from Biobool
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