COASY

Gene Symbol	COASY
Entrez Gene	80347
Alt Symbol	DPCK, NBIA6, NBP, PPAT, UKR1, pOV-2
Species	Human
Gene Type	protein-coding
Description	CoA synthase
Other Description	bifunctional coenzyme A synthase|bifunctional phosphopantetheine adenylyl transferase/dephospho CoA kinase|nucleotide binding protein|phosphopantetheine adenylyltransferase / dephosphocoenzyme A kinase
Swissprots	Q9NRM3 Q8WXD4 Q8NEW1 B2RA78 B4DLU0 Q8NBM7 Q6GS23 Q13057
Accessions	EAW60838 EAW60839 EAW60840 Q13057 AF208536 AAF87955 AF453478 AAL50813 AK075415 AK092498 AK225485 AK297153 BAG59652 AK303766 BAG64732 AK314076 BAG36775 AL360167 AL360168 AL583142 AL833588 AY094602 AAM19996 BC006354 AAH06354 BC020985 AAH20985 BC067254 AAH67254 BM473635 BM781531 BT007168 AAP35832 DA131866 DA786254 JF432607 ADZ15824 U18919 AAA69699 XM_006722116 XP_006722179 XM_011525300 XP_011523602 XM_011525301 XP_011523603 XR_429926 NM_001042529 NP_001035994 NM_001042532 NP_001035997 NM_025233 NP_079509 NM_001042530 NM_001042531
Function	Bifunctional enzyme that catalyzes the fourth and fifth sequential steps of CoA biosynthetic pathway. The fourth reaction is catalyzed by the phosphopantetheine adenylyltransferase, coded by the coaD domain; the fifth reaction is catalyzed by the dephospho-CoA kinase, coded by the coaE domain. May act as a point of CoA biosynthesis regulation. {ECO:0000269|PubMed:11923312}.
Subcellular Location	Cytoplasm {ECO:0000250}. Mitochondrion matrix {ECO:0000269|PubMed:24360804}. Note=The protein is mainly present in the mitochondrial matrix, probably anchored to the inner mitochondrial membrane, but is also present in cell lysate.
Tissue Specificity	Expressed in all tissues examined including brain, heart, skeletal muscle, colon, thymus, spleen, kidney, liver, small intestine, placenta, lung and peripheral blood leukocyte. Lowest expression in peripheral blood leukocytes and highest in kidney and liver. Isoform 2 is expressed mainly in the brain. {ECO:0000269|PubMed:11923312}.
Top Pathways	Pantothenate and CoA biosynthesis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

COASY CRISPR/Cas9 KO Plasmid (h) - sc-410157 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

COASY HDR Plasmid (h) - sc-410157-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

COASY Double Nickase Plasmid (h) - sc-410157-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

COASY Double Nickase Plasmid (h2) - sc-410157-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

COASY CRISPR Activation Plasmid (h) - sc-410157-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

COASY CRISPR Activation Plasmid (h2) - sc-410157-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

COASY Lentiviral Activation Particles (h) - sc-410157-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

COASY Lentiviral Activation Particles (h2) - sc-410157-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

COASY siRNA (h) - sc-93576 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

COASY shRNA Plasmid (h) - sc-93576-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

COASY shRNA (h) Lentiviral Particles - sc-93576-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

COASY RNAi - H00080347-R01V from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

COASY RNAi - H00080347-R02 from Novus Biologicals Category siRNA Prices $409.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU057551 from Sigma-Aldrich Category siRNA Prices $250.00 Sizes 50 µg

MISSION® siRNA - SIHK0479 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK0480 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK0476 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK0473 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK0478 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK0475 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK0477 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK0474 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

CompoZr® Knockout ZFN Kit - CKOZFN6353 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6353 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR01787 from Sigma-Aldrich Category miRNA Prices $350.00 Sizes hutr01787

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