COASY

Gene Symbol	COASY
Entrez Gene	80347
Alt Symbol	DPCK, NBIA6, NBP, PPAT, UKR1, pOV-2
Species	Human
Gene Type	protein-coding
Description	CoA synthase
Other Description	bifunctional coenzyme A synthase|bifunctional phosphopantetheine adenylyl transferase/dephospho CoA kinase|nucleotide binding protein|phosphopantetheine adenylyltransferase / dephosphocoenzyme A kinase
Swissprots	Q9NRM3 Q8WXD4 Q8NEW1 B2RA78 B4DLU0 Q8NBM7 Q6GS23 Q13057
Accessions	EAW60838 EAW60839 EAW60840 Q13057 AF208536 AAF87955 AF453478 AAL50813 AK075415 AK092498 AK225485 AK297153 BAG59652 AK303766 BAG64732 AK314076 BAG36775 AL360167 AL360168 AL583142 AL833588 AY094602 AAM19996 BC006354 AAH06354 BC020985 AAH20985 BC067254 AAH67254 BM473635 BM781531 BT007168 AAP35832 DA131866 DA786254 JF432607 ADZ15824 U18919 AAA69699 XM_006722116 XP_006722179 XM_011525300 XP_011523602 XM_011525301 XP_011523603 XR_429926 NM_001042529 NP_001035994 NM_001042532 NP_001035997 NM_025233 NP_079509 NM_001042530 NM_001042531
Function	Bifunctional enzyme that catalyzes the fourth and fifth sequential steps of CoA biosynthetic pathway. The fourth reaction is catalyzed by the phosphopantetheine adenylyltransferase, coded by the coaD domain; the fifth reaction is catalyzed by the dephospho-CoA kinase, coded by the coaE domain. May act as a point of CoA biosynthesis regulation. {ECO:0000269|PubMed:11923312}.
Subcellular Location	Cytoplasm {ECO:0000250}. Mitochondrion matrix {ECO:0000269|PubMed:24360804}. Note=The protein is mainly present in the mitochondrial matrix, probably anchored to the inner mitochondrial membrane, but is also present in cell lysate.
Tissue Specificity	Expressed in all tissues examined including brain, heart, skeletal muscle, colon, thymus, spleen, kidney, liver, small intestine, placenta, lung and peripheral blood leukocyte. Lowest expression in peripheral blood leukocytes and highest in kidney and liver. Isoform 2 is expressed mainly in the brain. {ECO:0000269|PubMed:11923312}.
Top Pathways	Pantothenate and CoA biosynthesis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human COASY (phospho S182) peptide - ab46197 from Abcam Category Peptide

Human COASY full length protein - ab164267 from Abcam Category Protein Source Wheat germ Species Human

Human COASY protein fragment - ab164268 from Abcam Category Protein Source Wheat germ Species Human

COASY Antibody Blocking Peptide - LS-E24156 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human COASY Protein - H00080347-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human COASY Protein - H00080347-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

COASY-Antibody-Center-Blocking-peptide - BP10371c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Human COASY protein (His Tag) - orb138600 from Biorbyt Category Protein Prices $323.00, $646.00 Sizes 20 μg, 100 μg Source E. coli Species Human

COASY Blocking Peptide - abx063989 from Abbexa Category Peptide Species Human, Mouse

CoA synthase - H00080347-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

CoA synthase - H00080347-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

CoA synthase - H00080347-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

CoA synthase - H00080347-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

COASY fusion protein - Ag3651 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human COASY, GST-tagged - COASY-11415H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human COASY, His-tagged - COASY-263H from Creative Biomart Category Protein Source E. coli Species Human

Human COASY / CoA synthase Protein (His Tag) - 15397-H07E-100 from Sino Biological Category Protein Source E. coli Species Human

COASY Blocking Peptide - CBP2795 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse

Recombinant Human Bifunctional coenzyme A synthase(COASY) - CSB-YP618754HU CSB-EP618754HU CSB-BP618754HU CSB-MP618754HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

CoA synthase (transcript variant 2) - TP315228 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

CoA synthase (transcript variant 1) - TP320733 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

COASY Recombinant Protein Antigen - NBP1-84991PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

COASY Recombinant Protein Antigen - NBP1-84990PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

COASY Recombinant Protein Antigen - NBP1-84989PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

COASY Peptide, Human - M34GP03418H from Creative Peptides Category Peptide Source Synthetic. Species Human

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