MLKL

Gene Symbol	MLKL
Entrez Gene	197259
Alt Symbol	hMLKL
Species	Human
Gene Type	protein-coding
Description	mixed lineage kinase domain-like
Other Description	mixed lineage kinase domain-like protein
Swissprots	Q8NB16 A6NCE4 Q8N6V0
Accessions	CAH25906 EAW95679 Q8NB16 AK091708 BAC03728 AK093013 AK122998 AL833362 CAI46144 BC028141 AAH28141 BQ575071 XM_005255834 XP_005255891 XM_011522934 XP_011521236 XM_011522935 XP_011521237 XM_011522936 XP_011521238 XR_243397 XR_429715 XR_429716 XR_933232 XR_933233 NM_001142497 NP_001135969 NM_152649 NP_689862
Function	Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process. Activated following phosphorylation by RIPK3, leading to homotrimerization, localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage. Does not have protein kinase activity. {ECO:0000269|PubMed:22265413, ECO:0000269|PubMed:22265414, ECO:0000269|PubMed:22421439, ECO:0000269|PubMed:24316671}.
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:24316671}. Cell membrane {ECO:0000269|PubMed:24316671}. Note=Localizes to the cytoplasm and translocates to the plasma membrane on necroptosis induction.
Top Pathways	TNF signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human MLKL ELISA Kit - abx054226 from Abbexa Category ELISA Kit

Mixed lineage kinase domain-like protein, MLKL, Human, ELISA Kit - E1747h from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t

mixed lineage kinase domain-like (MLKL), ELISA Kit - MBS9312153 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

mixed lineage kinase domain-like, MLKL, ELISA Kit - MBS9300811 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 10 pg/ml Range 62.5 pg/ml - 2000 pg/ml

Human MLKL ELISA Kit (Sandwich ELISA) - LS-F18428 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.156 ng/ml Range 0.156-10 ng/ml

Mouse MLKL ELISA Kit (Custom ELISA) - LS-F18429 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 0.156-10 ng/ml

Human Mixed lineage kinase domain-like protein ELISA Kit - EKE54014 from Biomatik Category ELISA Kit Prices $685.00, $2,913.00, $5,483.00 Sizes 96 t, 5x96t, 10x96t Range 0.156-10 ng/mL

Human MLKL ELISA Kit - E024765 from Biobool Category ELISA Kit

MLKL ELISA Kit (Human) (OKEH03401) - OKEH03401 from Aviva Systems Biology Category ELISA Kit Prices $425.00 Sizes 96 wells Sensitivity 0.078 ng/mL Range 0.156 - 10 ng/mL

Human Mixed lineage kinase domain-like protein ELISA Kit - EK3932 from Signalway Antibody Category ELISA Kit Prices $599.00 Sizes 1x96t Sensitivity less than 4.6 pg/mL Range 15.6-1000 pg/mL

anti-MLKL antibody - ARG56456 from Arigo Biolaboratories Category ELISA Kit

anti-MLKL antibody - ARG54860 from Arigo Biolaboratories Category ELISA Kit

Human Mixed lineage kinase domain-like (MLKL) ELISA Kit - AE60437HU from ARP American Research Products Category ELISA Kit Prices $549.00 Sizes 96 t Sensitivity 0.053 ng/mL Range 0.156-10 ng/mL

Mixed Lineage Kinase Domain-Like (MLKL), ELISA Kit - MBS9345849 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Mixed Lineage Kinase Domain-Like (MLKL), ELISA Kit - MBS9352817 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Mixed Lineage Kinase Domain-Like (MLKL), ELISA Kit - MBS9363688 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Mixed Lineage Kinase Domain-Like (MLKL), ELISA Kit - MBS9367406 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Mixed Lineage Kinase Domain-Like (MLKL), ELISA Kit - MBS9369408 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Mixed Lineage Kinase Domain-Like (MLKL), ELISA Kit - MBS9359261 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.1ng/ml Range 0.625ng/ml-20ng/ml

Mixed Lineage Kinase Domain-Like (MLKL), ELISA Kit - MBS9365918 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Mixed Lineage Kinase Domain-Like (MLKL), ELISA Kit - MBS9357206 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Mixed Lineage Kinase Domain-Like (MLKL), ELISA Kit - MBS9361935 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Mixed Lineage Kinase Domain-Like (MLKL), ELISA Kit - MBS9348482 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Mixed Lineage Kinase Domain-Like (MLKL), ELISA Kit - MBS9366828 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Mixed Lineage Kinase Domain-Like (MLKL), ELISA Kit - MBS9344347 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

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