MLKL

Gene Symbol	MLKL
Entrez Gene	197259
Alt Symbol	hMLKL
Species	Human
Gene Type	protein-coding
Description	mixed lineage kinase domain-like
Other Description	mixed lineage kinase domain-like protein
Swissprots	Q8NB16 A6NCE4 Q8N6V0
Accessions	CAH25906 EAW95679 Q8NB16 AK091708 BAC03728 AK093013 AK122998 AL833362 CAI46144 BC028141 AAH28141 BQ575071 XM_005255834 XP_005255891 XM_011522934 XP_011521236 XM_011522935 XP_011521237 XM_011522936 XP_011521238 XR_243397 XR_429715 XR_429716 XR_933232 XR_933233 NM_001142497 NP_001135969 NM_152649 NP_689862
Function	Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process. Activated following phosphorylation by RIPK3, leading to homotrimerization, localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage. Does not have protein kinase activity. {ECO:0000269|PubMed:22265413, ECO:0000269|PubMed:22265414, ECO:0000269|PubMed:22421439, ECO:0000269|PubMed:24316671}.
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:24316671}. Cell membrane {ECO:0000269|PubMed:24316671}. Note=Localizes to the cytoplasm and translocates to the plasma membrane on necroptosis induction.
Top Pathways	TNF signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

MLKL CRISPR/Cas9 KO Plasmid (h) - sc-401248 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

MLKL HDR Plasmid (h) - sc-401248-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

MLKL Double Nickase Plasmid (h) - sc-401248-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

MLKL Double Nickase Plasmid (h2) - sc-401248-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

MLKL CRISPR Activation Plasmid (h) - sc-401248-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

MLKL CRISPR Activation Plasmid (h2) - sc-401248-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

MLKL Lentiviral Activation Particles (h) - sc-401248-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

MLKL Lentiviral Activation Particles (h2) - sc-401248-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

MLKL siRNA (h) - sc-93430 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

MLKL shRNA Plasmid (h) - sc-93430-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

MLKL shRNA (h) Lentiviral Particles - sc-93430-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

MLKL RNAi - H00197259-R02 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU072661 from Sigma-Aldrich Category siRNA Prices $250.00 Sizes 50 µg

MISSION® siRNA - SIHK1307 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK1309 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK1308 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

CompoZr® Knockout ZFN Kit - CKOZFN14395 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND14395 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR05889 from Sigma-Aldrich Category miRNA Prices $350.00 Sizes hutr05889

MLKL siRNA (Human) - CRJ6198 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human MLKL (NM_152649.2) - SHH342492 from Creative biogene Category siRNA Species Reactivities Human

Human MLKL siRNA - orb276699 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

MLKL shRNA Plasmid (Human) - CHJ6198 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

MLKL miRNA 3'UTR clone - MiUTR1H-06322 from Creative biogene Species Reactivities Human

MLKL miRNA 3'UTR clone - MiUTR3H-15506 from Creative biogene Species Reactivities Human

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