MLKL

Gene Symbol	MLKL
Entrez Gene	197259
Alt Symbol	hMLKL
Species	Human
Gene Type	protein-coding
Description	mixed lineage kinase domain-like
Other Description	mixed lineage kinase domain-like protein
Swissprots	Q8NB16 A6NCE4 Q8N6V0
Accessions	CAH25906 EAW95679 Q8NB16 AK091708 BAC03728 AK093013 AK122998 AL833362 CAI46144 BC028141 AAH28141 BQ575071 XM_005255834 XP_005255891 XM_011522934 XP_011521236 XM_011522935 XP_011521237 XM_011522936 XP_011521238 XR_243397 XR_429715 XR_429716 XR_933232 XR_933233 NM_001142497 NP_001135969 NM_152649 NP_689862
Function	Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process. Activated following phosphorylation by RIPK3, leading to homotrimerization, localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage. Does not have protein kinase activity. {ECO:0000269|PubMed:22265413, ECO:0000269|PubMed:22265414, ECO:0000269|PubMed:22421439, ECO:0000269|PubMed:24316671}.
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:24316671}. Cell membrane {ECO:0000269|PubMed:24316671}. Note=Localizes to the cytoplasm and translocates to the plasma membrane on necroptosis induction.
Top Pathways	TNF signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human MLKL full length protein - ab153623 from Abcam Category Protein Source Wheat germ Species Human

Human MLKL protein fragment - ab153624 from Abcam Category Protein Source Wheat germ Species Human

MLKL Antibody Blocking Peptide - LS-E3132 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

MLKL Antibody Blocking Peptide - LS-E19137 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

MLKL Recombinant Protein - H00197259-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Species Human

Recombinant Human MLKL Protein - H00197259-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

MLKL Peptide - P2309 from Novus Biologicals Category Peptide Species Human

MLKL-Antibody-N-term-Blocking-Peptide - BP7153a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Human MLKL protein - orb246286 from Biorbyt Category Protein Prices $213.00, $408.00, $680.00, $1,122.00, $1,777.00 Sizes 10 μg, 50 μg, 200 μg, 500 μg, 1 mg Species Human

Human MLKL protein - orb246613 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

MLKL Blocking Peptide - 33R-2230 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

MLKL - H00197259-P01 from Acris Antibodies Category Protein Prices $340.00 Sizes 2 µg Species Human

MLKL - H00197259-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

MLKL - H00197259-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

MLKL fusion protein - Ag15188 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

MLKL fusion protein - Ag15626 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

Recombinant Human MLKL, GST-tagged - MLKL-905H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human MLKL, GST-tagged - MLKL-95H from Creative Biomart Category Protein Source Wheat germ Species Human

Recombinant Human Mixed lineage kinase domain-like protein(MLKL) - CSB-EP850851HU CSB-BP850851HU CSB-MP850851HU from Cusabio Category Protein Source E.coli or Baculovirus or Mammalian cell Species Human

Recombinant Human Mixed lineage kinase domain-like protein(MLKL) - CSB-EP850851HU from Cusabio Category Protein Source Yeast Species Human

Recombinant Homo sapiens Mixed lineage kinase domain-like protein - CSB-YP850851HU CSB-BP850851HU CSB-MP850851HU from Cusabio Category Protein Source Yeast or Baculovirus or Mammalian cell

MLKL Peptide, Human - M34GP09562H from Creative Peptides Category Peptide Source Synthetic. Species Human

MLKL Recombinant Protein (OPCA02427) - OPCA02427 from Aviva Systems Biology Category Protein Prices $250.00 Sizes 50 µg Species Human

MLKL Recombinant Protein (OPCA03057) - OPCA03057 from Aviva Systems Biology Category Protein Prices $250.00 Sizes 50 µg Source Human

Recombinant human Mixed lineage kinase domain-like protein - AP71474 from Signalway Antibody Category Protein Prices $260.00, $735.00, $1,240.00, $1,975.00 Sizes 50 µg, 200 µg, 500 µg, 1 mg Source E.coli Species Human

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