| Gene Symbol |
MLKL
|
| Entrez Gene |
197259
|
| Alt Symbol |
hMLKL
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
mixed lineage kinase domain-like
|
| Other Description |
mixed lineage kinase domain-like protein
|
| Swissprots |
Q8NB16 A6NCE4 Q8N6V0
|
| Accessions |
CAH25906 EAW95679 Q8NB16 AK091708 BAC03728 AK093013 AK122998 AL833362 CAI46144 BC028141 AAH28141 BQ575071 XM_005255834 XP_005255891 XM_011522934 XP_011521236 XM_011522935 XP_011521237 XM_011522936 XP_011521238 XR_243397 XR_429715 XR_429716 XR_933232 XR_933233 NM_001142497 NP_001135969 NM_152649 NP_689862
|
| Function |
Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process. Activated following phosphorylation by RIPK3, leading to homotrimerization, localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage. Does not have protein kinase activity. {ECO:0000269|PubMed:22265413, ECO:0000269|PubMed:22265414, ECO:0000269|PubMed:22421439, ECO:0000269|PubMed:24316671}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:24316671}. Cell membrane {ECO:0000269|PubMed:24316671}. Note=Localizes to the cytoplasm and translocates to the plasma membrane on necroptosis induction.
|
| Top Pathways |
TNF signaling pathway
|