WT1

Gene Symbol WT1
Entrez Gene 7490
Alt Symbol AWT1, EWS-WT1, GUD, NPHS4, WAGR, WIT-2, WT33
Species Human
Gene Type protein-coding
Description Wilms tumor 1
Other Description Wilms tumor protein|amino-terminal domain of EWS|last three zinc fingers of the DNA-binding domain of WT1
Swissprots Q4VXV4 Q16575 Q16256 Q15881 A8K6S1 Q4VXV6 Q4VXV5 Q8IYZ5 B3KSA5 P19544
Accessions AAA61299 AAA62865 AAB19895 AAB20109 AAB20110 AAB20111 AAB20112 AAC60604 AAC60605 AAD14879 AAO61088 AAR06172 ABK15552 ABK15553 AGX31264 AHH02461 BAF85820 CAA43819 CAA51057 CAA51062 EAW68220 EAW68221 EAW68222 EAW68223 EAW68224 EAW68225 EAW68226 P19544 AK093168 BAG52667 AK291736 BAF84425 BC032861 AAH32861 BC046461 AAH46461 BG718348 JF432657 ADZ15874 M30393 AAA36810 S74529 AAB33427 S75264 AAB33443 X51630 CAA35956 NM_000378 NP_000369 NM_001198551 NP_001185480 NM_001198552 NP_001185481 NM_024424 NP_077742 NM_024426 NP_077744 NM_024425
Function Transcription factor that plays an important role in cellular development and cell survival. Regulates the expression of numerous target genes, including EPO. Plays an essential role for development of the urogenital system. Recognizes and binds to the DNA sequence 5'-CGCCCCCGC-3'. It has a tumor suppressor as well as an oncogenic role in tumor formation. Function may be isoform-specific: isoforms lacking the KTS motif may act as transcription factors. Isoforms containing the KTS motif may bind mRNA and play a role in mRNA metabolism or splicing. Isoform 1 has lower affinity for DNA, and can bind RNA. {ECO:0000269|PubMed:19123921, ECO:0000269|PubMed:19416806}.
Subcellular Location Isoform 4: Nucleus, nucleoplasm.
Tissue Specificity Expressed in the kidney and a subset of hematopoietic cells.
Top Pathways Transcriptional misregulation in cancer

WT1-Over-expression-Lysate - LY14025a from Abgent, a WuXi AppTec company

Category Cell Lysate
Prices $325.00
Sizes 100 µg
Western blot analysis of his-tag WT1 (arrow) using his tag antibody. 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the WT1 gene.

WT1 293 Cell Lysate - 402601 from ABBIOTEC

Category Cell Lysate
Prices $672.00
Sizes 100 µg
Disease Tumor

WT1 Overexpression Lysate (Native) - NBP2-11141 from Novus Biologicals

Category Cell Lysate
Prices $529.00
Sizes 100 µg
Western Blot: Wilms Tumor 1 Overexpression Lysate (Adult Normal) [NBP2-11141] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Wilms Tumor 1.

WT1 (h): 293T Lysate - sc-117178 from Santa Cruz Biotechnology

Category Cell Lysate
Prices $205.00
Sizes 100 µg/200 µl
Species Human

WT1 Over-expression Lysate Product - GWB-41C1E8 from Genway Biotech

Category Cell Lysate
Prices $756.00
Sizes 100 µg
Disease Tumor

WT1 Overexpression Lysate (Native) - NBP2-11168 from Novus Biologicals

Category Cell Lysate
Prices $329.00
Sizes 100 µg
Western Blot: Wilms Tumor 1 Overexpression Lysate (Adult Normal) [NBP2-11168] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Wilms Tumor 1.

WT1 Overexpression Lysate (Denatured) - H00007490-T02 from Novus Biologicals

Category Cell Lysate
Prices $279.00
Sizes 100 µl

Panoply™ Human WT1 Knockdown Stable Cell Line - CSC-DC017539 from Creative biogene

Category Cell Line
Species Human
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