WT1
| Gene Symbol | WT1 |
|---|---|
| Entrez Gene | 7490 |
| Alt Symbol | AWT1, EWS-WT1, GUD, NPHS4, WAGR, WIT-2, WT33 |
| Species | Human |
| Gene Type | protein-coding |
| Description | Wilms tumor 1 |
| Other Description | Wilms tumor protein|amino-terminal domain of EWS|last three zinc fingers of the DNA-binding domain of WT1 |
| Swissprots | Q4VXV4 Q16575 Q16256 Q15881 A8K6S1 Q4VXV6 Q4VXV5 Q8IYZ5 B3KSA5 P19544 |
| Accessions | AAA61299 AAA62865 AAB19895 AAB20109 AAB20110 AAB20111 AAB20112 AAC60604 AAC60605 AAD14879 AAO61088 AAR06172 ABK15552 ABK15553 AGX31264 AHH02461 BAF85820 CAA43819 CAA51057 CAA51062 EAW68220 EAW68221 EAW68222 EAW68223 EAW68224 EAW68225 EAW68226 P19544 AK093168 BAG52667 AK291736 BAF84425 BC032861 AAH32861 BC046461 AAH46461 BG718348 JF432657 ADZ15874 M30393 AAA36810 S74529 AAB33427 S75264 AAB33443 X51630 CAA35956 NM_000378 NP_000369 NM_001198551 NP_001185480 NM_001198552 NP_001185481 NM_024424 NP_077742 NM_024426 NP_077744 NM_024425 |
| Function | Transcription factor that plays an important role in cellular development and cell survival. Regulates the expression of numerous target genes, including EPO. Plays an essential role for development of the urogenital system. Recognizes and binds to the DNA sequence 5'-CGCCCCCGC-3'. It has a tumor suppressor as well as an oncogenic role in tumor formation. Function may be isoform-specific: isoforms lacking the KTS motif may act as transcription factors. Isoforms containing the KTS motif may bind mRNA and play a role in mRNA metabolism or splicing. Isoform 1 has lower affinity for DNA, and can bind RNA. {ECO:0000269|PubMed:19123921, ECO:0000269|PubMed:19416806}. |
| Subcellular Location | Isoform 4: Nucleus, nucleoplasm. |
| Tissue Specificity | Expressed in the kidney and a subset of hematopoietic cells. |
| Top Pathways | Transcriptional misregulation in cancer |
WT1 CRISPR/Cas9 KO Plasmid (h) - sc-400095 from Santa Cruz Biotechnology
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WT1 HDR Plasmid (h) - sc-400095-HDR from Santa Cruz Biotechnology
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WT1 Double Nickase Plasmid (h) - sc-400095-NIC from Santa Cruz Biotechnology
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WT1 Double Nickase Plasmid (h2) - sc-400095-NIC-2 from Santa Cruz Biotechnology
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WT1 CRISPR Activation Plasmid (h) - sc-400095-ACT from Santa Cruz Biotechnology
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WT1 CRISPR Activation Plasmid (h2) - sc-400095-ACT-2 from Santa Cruz Biotechnology
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WT1 Lentiviral Activation Particles (h) - sc-400095-LAC from Santa Cruz Biotechnology
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WT1 Lentiviral Activation Particles (h2) - sc-400095-LAC-2 from Santa Cruz Biotechnology
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WT1 siRNA (h) - sc-36846 from Santa Cruz Biotechnology
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WT1 shRNA Plasmid (h) - sc-36846-SH from Santa Cruz Biotechnology
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WT1 shRNA (h) Lentiviral Particles - sc-36846-V from Santa Cruz Biotechnology
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WT1 RNAi - H00007490-R04 from Novus Biologicals
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WT1 RNAi - H00007490-R02 from Novus Biologicals
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MISSION® esiRNA - EHU083661 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN22936 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22936 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR08780 from Sigma-Aldrich
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WT1 siRNA (Human) - CRH5126 from Cohesion Biosciences
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WT1 RNAi - H00007490-R01 from Novus Biologicals
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WT1 RNAi - H00007490-R03 from Novus Biologicals
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WT1 - MBS8224253 from MyBioSource
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shRNA set against Human WT1 (NM_000378.4) - SHH447524 from Creative biogene
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Human WT1 siRNA - orb265628 from Biorbyt
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WT1 shRNA Plasmid (Human) - CHH5126 from Cohesion Biosciences
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WT1 miRNA 3'UTR clone - MiUTR3H-08968 from Creative biogene
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