WT1

Gene Symbol	WT1
Entrez Gene	7490
Alt Symbol	AWT1, EWS-WT1, GUD, NPHS4, WAGR, WIT-2, WT33
Species	Human
Gene Type	protein-coding
Description	Wilms tumor 1
Other Description	Wilms tumor protein|amino-terminal domain of EWS|last three zinc fingers of the DNA-binding domain of WT1
Swissprots	Q4VXV4 Q16575 Q16256 Q15881 A8K6S1 Q4VXV6 Q4VXV5 Q8IYZ5 B3KSA5 P19544
Accessions	AAA61299 AAA62865 AAB19895 AAB20109 AAB20110 AAB20111 AAB20112 AAC60604 AAC60605 AAD14879 AAO61088 AAR06172 ABK15552 ABK15553 AGX31264 AHH02461 BAF85820 CAA43819 CAA51057 CAA51062 EAW68220 EAW68221 EAW68222 EAW68223 EAW68224 EAW68225 EAW68226 P19544 AK093168 BAG52667 AK291736 BAF84425 BC032861 AAH32861 BC046461 AAH46461 BG718348 JF432657 ADZ15874 M30393 AAA36810 S74529 AAB33427 S75264 AAB33443 X51630 CAA35956 NM_000378 NP_000369 NM_001198551 NP_001185480 NM_001198552 NP_001185481 NM_024424 NP_077742 NM_024426 NP_077744 NM_024425
Function	Transcription factor that plays an important role in cellular development and cell survival. Regulates the expression of numerous target genes, including EPO. Plays an essential role for development of the urogenital system. Recognizes and binds to the DNA sequence 5'-CGCCCCCGC-3'. It has a tumor suppressor as well as an oncogenic role in tumor formation. Function may be isoform-specific: isoforms lacking the KTS motif may act as transcription factors. Isoforms containing the KTS motif may bind mRNA and play a role in mRNA metabolism or splicing. Isoform 1 has lower affinity for DNA, and can bind RNA. {ECO:0000269|PubMed:19123921, ECO:0000269|PubMed:19416806}.
Subcellular Location	Isoform 4: Nucleus, nucleoplasm.
Tissue Specificity	Expressed in the kidney and a subset of hematopoietic cells.
Top Pathways	Transcriptional misregulation in cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

WT1 (D6M6S) Rabbit mAb - 13580 from Cell Signaling Technology Prices $246.00 Sizes 100 µl (10 western blots) Host Rabbit Clonality Monoclonal Clone D6M6S

WT1 (H-1) - sc-393498 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

WT1 (C-19) - sc-192 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

WT1 (F-6) - sc-7385 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

WT1 (N-20) - sc-15421 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

WT1 (H-290) - sc-68880 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

p-WT (Ser 363) - sc-12933 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

p-WT (Ser 393) - sc-12934 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-Wilms Tumor Protein antibody - ab96792 from Abcam Prices $390.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-Wilms Tumor Protein antibody - ab15249 from Abcam Prices $382.00 Sizes 500 µl Host Rabbit Clonality Polyclonal

Anti-Wilms Tumor Protein antibody - ab180840 from Abcam Prices $384.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-Wilms Tumor Protein antibody - ab51951 from Abcam Prices $376.00 Sizes 200 µl Host Goat Clonality Polyclonal

Anti-Wilms Tumor Protein antibody - ab58062 from Abcam Prices $376.00 Sizes 100 µg Host Mouse Clonality Monoclonal

Anti-Wilms Tumor Protein antibody - ab86522 from Abcam Prices $376.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-Wilms Tumor Protein antibody [1E9] - ab118873 from Abcam Prices $378.00 Sizes 50 µg Host Mouse Clonality Monoclonal Clone 1E9

Anti-Wilms Tumor Protein antibody [5G11A5] - ab201948 from Abcam Prices $359.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 5G11A5

Anti-Wilms Tumor Protein antibody [6F-H2] - ab93050 from Abcam Prices $370.00 Sizes 500 µl Host Mouse Clonality Monoclonal Clone 6F-H2

Anti-Wilms Tumor Protein antibody [CAN-R9(IHC)-56-2] - ab89901 from Abcam Prices $400.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone CAN-R9(IHC)-56-2

Anti-Wilms Tumor Protein antibody, prediluted - ab15250 from Abcam Prices $376.00 Sizes 7 ml Host Rabbit Clonality Polyclonal

Anti-WT1 / Wilms Tumor 1 Antibody (aa1-181) - LS-C40253 from LifeSpan Bioscience Prices $365.00 Sizes 500 µl Host Mouse Clonality Monoclonal

Anti-WT1 / Wilms Tumor 1 Antibody (N-Terminus, clone 6F-H2) - LS-C95612 from LifeSpan Bioscience Prices $380.00, $605.00 Sizes 500 µl, 1 ml Host Mouse Clonality Monoclonal Clone 6F-H2

Anti-WT1 / Wilms Tumor 1 Antibody (aa1-181, clone 6F-H2, Biotin) - LS-C141654 from LifeSpan Bioscience Prices $365.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 6F-H2

Anti-WT1 / Wilms Tumor 1 Antibody (aa1-181, clone 6F-H2, DY650) - LS-C141655 from LifeSpan Bioscience Prices $365.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 6F-H2

Anti-WT1 / Wilms Tumor 1 Antibody (aa1-181, clone 6F-H2, DY488) - LS-C141656 from LifeSpan Bioscience Prices $365.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 6F-H2

Anti-WT1 / Wilms Tumor 1 Antibody (aa16-30) - LS-C55689 from LifeSpan Bioscience Prices $395.00 Sizes 100 µg Host Goat Clonality Polyclonal

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