WT1

Gene Symbol	WT1
Entrez Gene	7490
Alt Symbol	AWT1, EWS-WT1, GUD, NPHS4, WAGR, WIT-2, WT33
Species	Human
Gene Type	protein-coding
Description	Wilms tumor 1
Other Description	Wilms tumor protein|amino-terminal domain of EWS|last three zinc fingers of the DNA-binding domain of WT1
Swissprots	Q4VXV4 Q16575 Q16256 Q15881 A8K6S1 Q4VXV6 Q4VXV5 Q8IYZ5 B3KSA5 P19544
Accessions	AAA61299 AAA62865 AAB19895 AAB20109 AAB20110 AAB20111 AAB20112 AAC60604 AAC60605 AAD14879 AAO61088 AAR06172 ABK15552 ABK15553 AGX31264 AHH02461 BAF85820 CAA43819 CAA51057 CAA51062 EAW68220 EAW68221 EAW68222 EAW68223 EAW68224 EAW68225 EAW68226 P19544 AK093168 BAG52667 AK291736 BAF84425 BC032861 AAH32861 BC046461 AAH46461 BG718348 JF432657 ADZ15874 M30393 AAA36810 S74529 AAB33427 S75264 AAB33443 X51630 CAA35956 NM_000378 NP_000369 NM_001198551 NP_001185480 NM_001198552 NP_001185481 NM_024424 NP_077742 NM_024426 NP_077744 NM_024425
Function	Transcription factor that plays an important role in cellular development and cell survival. Regulates the expression of numerous target genes, including EPO. Plays an essential role for development of the urogenital system. Recognizes and binds to the DNA sequence 5'-CGCCCCCGC-3'. It has a tumor suppressor as well as an oncogenic role in tumor formation. Function may be isoform-specific: isoforms lacking the KTS motif may act as transcription factors. Isoforms containing the KTS motif may bind mRNA and play a role in mRNA metabolism or splicing. Isoform 1 has lower affinity for DNA, and can bind RNA. {ECO:0000269|PubMed:19123921, ECO:0000269|PubMed:19416806}.
Subcellular Location	Isoform 4: Nucleus, nucleoplasm.
Tissue Specificity	Expressed in the kidney and a subset of hematopoietic cells.
Top Pathways	Transcriptional misregulation in cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Wilms Tumor Protein full length protein - ab159818 from Abcam Category Protein Source Wheat germ Species Human

Human Wilms Tumor Protein full length protein - ab82233 from Abcam Category Protein Source Baculovirus Species Human

Human Wilms Tumor Protein full length protein - ab83942 from Abcam Category Protein Source Baculovirus Species Human

Human Wilms Tumor Protein peptide - ab73466 from Abcam Category Peptide

Human Wilms Tumor Protein protein fragment - ab159819 from Abcam Category Protein Source Wheat germ Species Human

WT1 / Wilms Tumor 1 Antibody Blocking Peptide - LS-E1333 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

WT1 / Wilms Tumor 1 Antibody Blocking Peptide - LS-E26134 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

WT1 / Wilms Tumor 1 Antibody Blocking Peptide - LS-E13623 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

WT1 / Wilms Tumor 1 Antibody Blocking Peptide - LS-E13624 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human WT1 Protein - H00007490-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Source Wheat Germ Species Human

Recombinant Human WT1 Protein - H00007490-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

WT1-Antibody-Center-E361-Blocking-peptide - BP11964c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PAX6 (C Terminus) blocking peptide - GTX89350-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Rat

PAX6 (internal) blocking peptide - GTX89029-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Rat

Wilms Tumor 1 blocking peptide - GTX89257-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human

Human Wilms Tumor 1 (HEK293 Lysate) - orb197736 from Biorbyt Category Protein Prices $255.00 Sizes 100 μg Species Human

Human WT1 protein - orb245512 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

Wilms Tumor 1 protein - orb197753 from Biorbyt Category Protein Prices $374.00 Sizes 200 μl Species Human

Human WT1 protein - orb244632 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

Goat anti WT1 antibody Immunizing peptide - orb16771 from Biorbyt Category Peptide Prices $247.00 Sizes 100 μg Species Human, Mouse, Rat

WT1 Blocking Peptide - 33R-6981 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

WT1 Blocking Peptide - 33R-6321 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

Wilms Tumor Protein Peptide - AC21-0964-P from Abcore Category Protein Prices $160.00 Sizes 100 µg

WT1 / Wilms tumor protein - H00007490-P01 from Acris Antibodies Category Protein Prices $340.00 Sizes 2 µg Species Human

WT1 / Wilms tumor protein - H00007490-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

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