ATG4C

Gene Symbol ATG4C
Entrez Gene 84938
Alt Symbol APG4-C, APG4C, AUTL1, AUTL3
Species Human
Gene Type protein-coding
Description autophagy related 4C, cysteine peptidase
Other Description APG4 autophagy 4 homolog C|ATG4 autophagy related 4 homolog C|AUT-like 1, cysteine endopeptidase|AUT-like 3 cysteine endopeptidase|autophagin-3|autophagy-related cysteine endopeptidase 3|autophagy-related protein 4 homolog C|cysteine protease ATG4C
Swissprots Q96DT6 A6NLR8 D3DQ58 Q96K04
Accessions EAX06579 EAX06580 Q96DT6 AJ312234 CAC85556 AJ320169 CAC43939 AK027773 BAB55356 BC008395 BC018678 AAH18678 BC033024 AAH33024 BI518482 BM146035 BM720875 BQ777265 DB183325 DQ892482 ABM83408 DQ895693 ABM86619 XM_005271288 XP_005271345 XM_011542313 XP_011540615 XM_011542314 XP_011540616 NM_032852 NP_116241 NM_178221 NP_835739
Function Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Is not essential for autophagy development under normal conditions but is required for a proper autophagic response under stressful conditions such as prolonged starvation (By similarity). Cleaves the C-terminal amino acid of ATG8 family proteins MAP1LC3 and GABARAPL2, to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Has also an activity of delipidating enzyme for the PE-conjugated forms. {ECO:0000250, ECO:0000269|PubMed:21177865}.
Subcellular Location Cytoplasm {ECO:0000250}.
Tissue Specificity Highly expressed in skeletal muscle, heart, liver and testis. {ECO:0000269|PubMed:12446702}.
Top Pathways Regulation of autophagy

ATG4C-Over-expression-Lysate - LY10583a from Abgent, a WuXi AppTec company

Category Cell Lysate
Prices $325.00
Sizes 100 µg
Western blot analysis of his-tag ATG4C (arrow) using his tag antibody. 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the ATG4C gene (Lane 2, Cat. #LY10583a).

ATG4C 293T Cell Transient Overexpression Lysate(Denatured) - H00084938-T01 from Acris Antibodies

Category Cell Lysate
Prices $320.00
Sizes 100 µl

ATG4C overexpression lysate - LY403599 from Acris Antibodies

Category Cell Lysate
Prices $280.00
Sizes 100 µg

ATG4C 293 Cell Lysate - 403109 from ABBIOTEC

Category Cell Lysate
Prices $392.00
Sizes 100 µg

ATG4C Overexpression Lysate (Native) - NBL1-07798 from Novus Biologicals

Category Cell Lysate
Prices $329.00
Sizes 100 µg

ATG4C Overexpression Lysate (Native) - NBP2-05958 from Novus Biologicals

Category Cell Lysate
Prices $329.00
Sizes 100 µg
Western Blot: ATG4C Overexpression Lysate (Adult Normal) [NBP2-05958] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for ATG4C.

ATG4C Over-expression Lysate Product - GWB-253344 from Genway Biotech

Category Cell Lysate
Prices $346.00
Sizes 100 µg
Species Human

ATG4C Overexpression Lysate (Denatured) - H00084938-T01 from Novus Biologicals

Category Cell Lysate
Prices $279.00
Sizes 100 µl

ATG4C Overexpression Lysate (Denatured) - H00084938-T02 from Novus Biologicals

Category Cell Lysate
Prices $299.00
Sizes 100 µl

Panoply™ Human ATG4C Knockdown Stable Cell Line - CSC-DC001103 from Creative biogene

Category Cell Line
Species Human
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