ATG4C

Gene Symbol	ATG4C
Entrez Gene	84938
Alt Symbol	APG4-C, APG4C, AUTL1, AUTL3
Species	Human
Gene Type	protein-coding
Description	autophagy related 4C, cysteine peptidase
Other Description	APG4 autophagy 4 homolog C|ATG4 autophagy related 4 homolog C|AUT-like 1, cysteine endopeptidase|AUT-like 3 cysteine endopeptidase|autophagin-3|autophagy-related cysteine endopeptidase 3|autophagy-related protein 4 homolog C|cysteine protease ATG4C
Swissprots	Q96DT6 A6NLR8 D3DQ58 Q96K04
Accessions	EAX06579 EAX06580 Q96DT6 AJ312234 CAC85556 AJ320169 CAC43939 AK027773 BAB55356 BC008395 BC018678 AAH18678 BC033024 AAH33024 BI518482 BM146035 BM720875 BQ777265 DB183325 DQ892482 ABM83408 DQ895693 ABM86619 XM_005271288 XP_005271345 XM_011542313 XP_011540615 XM_011542314 XP_011540616 NM_032852 NP_116241 NM_178221 NP_835739
Function	Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Is not essential for autophagy development under normal conditions but is required for a proper autophagic response under stressful conditions such as prolonged starvation (By similarity). Cleaves the C-terminal amino acid of ATG8 family proteins MAP1LC3 and GABARAPL2, to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Has also an activity of delipidating enzyme for the PE-conjugated forms. {ECO:0000250, ECO:0000269|PubMed:21177865}.
Subcellular Location	Cytoplasm {ECO:0000250}.
Tissue Specificity	Highly expressed in skeletal muscle, heart, liver and testis. {ECO:0000269|PubMed:12446702}.
Top Pathways	Regulation of autophagy

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human ATG4C full length protein - ab153559 from Abcam Category Protein Prices $402.00 Sizes 10 µg Source Wheat germ Species Human

Human ATG4C full length protein - ab152007 from Abcam Category Protein Prices $188.00 Sizes 10 µg Source E. coli Species Human

AUTL1 / ATG4C Antibody Blocking Peptide - LS-E5585 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

AUTL1 / ATG4C Antibody Blocking Peptide - LS-E21538 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human ATG4C Protein - H00084938-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

APG4C-Antibody-N-term-Blocking-Peptide - BP1810a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

ATG4C Blocking Peptide - 33R-9128 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

ATG4C Blocking Peptide - abx161284 from Abbexa Category Peptide Species Human

APG4C / ATG4C - H00084938-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

APG4C / ATG4C - H00084938-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

Cysteine protease ATG4C, ATG4C, Human, Recombinant - 19-CE84 from ARP American Research Products Category Protein Prices $169.00 Sizes 10 µg Source E. coli Species Human

ATG4C Peptide - 7907P from ProSci Category Peptide Species Human

ATG4C fusion protein - Ag14207 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

ATG4C fusion protein - Ag14494 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

Recombinant Human ATG4C Enzyme - BP001733-CE84 from Syd Labs Category Protein Prices $180.00, $528.00, $2,640.00 Sizes 10 µg, 50 µg, 1 mg Source E. coli-derived. Species Human

Recombinant Human ATG4C, His-tagged - ATG4C-7865H from Creative Biomart Category Protein Source E. coli Species Human

Recombinant Human ATG4C, GST-tagged - ATG4C-9976H from Creative Biomart Category Protein Source E.coli Species Human

ATG4B 1-393aa - CMB-1264 from Reagent Proteins Category Protein Prices $539.00, $1,099.00 Sizes 100.00 µg, 500 µg Source E.coli Species Human

ATG4C Blocking Peptide - CBP3783 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human

Recombinant Human Cysteine protease ATG4C(ATG4C) - CSB-YP836199HU CSB-EP836199HU CSB-BP836199HU CSB-MP836199HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

ATG4C Protein - abx164337 from Abbexa Category Protein Species Human, Mouse, Rat

APG4C / ATG4C (transcript variant 8) - TP305955 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

APG4C / ATG4C (transcript variant 7) - TP316088 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

APG4C / ATG4C (transcript variant 7) - TP720575 from Acris Antibodies Category Protein Prices $299.00 Sizes 10 µg Source E. coli Species Human

ATG4C, Peptide - MBS428175 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human, Dog, Bovine

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