| Gene Symbol | ATG4C |
|---|---|
| Entrez Gene | 84938 |
| Alt Symbol | APG4-C, APG4C, AUTL1, AUTL3 |
| Species | Human |
| Gene Type | protein-coding |
| Description | autophagy related 4C, cysteine peptidase |
| Other Description | APG4 autophagy 4 homolog C|ATG4 autophagy related 4 homolog C|AUT-like 1, cysteine endopeptidase|AUT-like 3 cysteine endopeptidase|autophagin-3|autophagy-related cysteine endopeptidase 3|autophagy-related protein 4 homolog C|cysteine protease ATG4C |
| Swissprots | Q96DT6 A6NLR8 D3DQ58 Q96K04 |
| Accessions | EAX06579 EAX06580 Q96DT6 AJ312234 CAC85556 AJ320169 CAC43939 AK027773 BAB55356 BC008395 BC018678 AAH18678 BC033024 AAH33024 BI518482 BM146035 BM720875 BQ777265 DB183325 DQ892482 ABM83408 DQ895693 ABM86619 XM_005271288 XP_005271345 XM_011542313 XP_011540615 XM_011542314 XP_011540616 NM_032852 NP_116241 NM_178221 NP_835739 |
| Function | Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Is not essential for autophagy development under normal conditions but is required for a proper autophagic response under stressful conditions such as prolonged starvation (By similarity). Cleaves the C-terminal amino acid of ATG8 family proteins MAP1LC3 and GABARAPL2, to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Has also an activity of delipidating enzyme for the PE-conjugated forms. {ECO:0000250, ECO:0000269|PubMed:21177865}. |
| Subcellular Location | Cytoplasm {ECO:0000250}. |
| Tissue Specificity | Highly expressed in skeletal muscle, heart, liver and testis. {ECO:0000269|PubMed:12446702}. |
| Top Pathways | Regulation of autophagy |