ATG4C

Gene Symbol ATG4C
Entrez Gene 84938
Alt Symbol APG4-C, APG4C, AUTL1, AUTL3
Species Human
Gene Type protein-coding
Description autophagy related 4C, cysteine peptidase
Other Description APG4 autophagy 4 homolog C|ATG4 autophagy related 4 homolog C|AUT-like 1, cysteine endopeptidase|AUT-like 3 cysteine endopeptidase|autophagin-3|autophagy-related cysteine endopeptidase 3|autophagy-related protein 4 homolog C|cysteine protease ATG4C
Swissprots Q96DT6 A6NLR8 D3DQ58 Q96K04
Accessions EAX06579 EAX06580 Q96DT6 AJ312234 CAC85556 AJ320169 CAC43939 AK027773 BAB55356 BC008395 BC018678 AAH18678 BC033024 AAH33024 BI518482 BM146035 BM720875 BQ777265 DB183325 DQ892482 ABM83408 DQ895693 ABM86619 XM_005271288 XP_005271345 XM_011542313 XP_011540615 XM_011542314 XP_011540616 NM_032852 NP_116241 NM_178221 NP_835739
Function Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Is not essential for autophagy development under normal conditions but is required for a proper autophagic response under stressful conditions such as prolonged starvation (By similarity). Cleaves the C-terminal amino acid of ATG8 family proteins MAP1LC3 and GABARAPL2, to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Has also an activity of delipidating enzyme for the PE-conjugated forms. {ECO:0000250, ECO:0000269|PubMed:21177865}.
Subcellular Location Cytoplasm {ECO:0000250}.
Tissue Specificity Highly expressed in skeletal muscle, heart, liver and testis. {ECO:0000269|PubMed:12446702}.
Top Pathways Regulation of autophagy

Atg4C Antibody - 5262 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from HeLa cells, transfected with 100 nM SignalSilence ® Control siRNA (Unconjugated) #6568 (-) or SignalSilence ® Atg4C siRNA I (+), using Atg4C Antibody #5262 (upper) or β-Tubulin (9F3) Rabbit mAb #2128 (lower). The Atg4C Antibody confirms silencing of Atg4C expression, while the β-Tubulin (9F3) Rabbit mAb is used as a loading control.

Atg4C (H-46) - sc-382812 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

Atg4C (K-15) - sc-163707 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Atg4C (T-13) - sc-163708 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Atg4C (T-13): sc-163708. Western blot analysis of Atg4C expression in Jurkat whole cell lysate.

Anti-ATG4C antibody - ab75056 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Human liver carcinoma tissue with ab75056 at 1/50 dilution. 1) Without immunising peptide 2) With immunising peptide

Anti-ATG4C antibody - ab62113 from Abcam

Host Sheep
Clonality Polyclonal

Anti-ATG4C antibody - ab89417 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Anti-ATG4C antibody (ab89417) at 1 µg/ml + human kidney tissue lysate at 50 µg

Anti-ATG4C antibody - ab176596 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-ATG4C antibody (ab176596) at 1/500 dilutionLane 1 : K562 cell lysateLane 2 : Hela cell lysateLane 3 : HepG2 cell lysateLane 4 : Jurkat cell lysate

Anti-ATG4C antibody [EPR15001] - ab183516 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR15001
All lanes : Anti-ATG4C antibody [EPR15001] (ab183516) at 1/20000 dilutionLane 1 : Jurkat cell lysateLane 2 : Raji cell lysateLane 3 : 293 cell lysateLysates/proteins at 20 µg per lane.SecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/1000 dilution

Anti-ATG4C antibody - C-terminal - ab191705 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-ATG4C antibody - C-terminal (ab191705) at 1 µg/ml + A549 cell lysate at 15 µg

Anti-ATG4C antibody - N-terminal - ab173796 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-ATG4C antibody - N-terminal (ab173796) at 1/100 dilution + Jurkat cell line lysate at 35 µg

Anti-AUTL1 / ATG4C Antibody (aa174-198) - LS-C47467 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-AUTL1 / ATG4C Antibody (C-Terminus) - LS-C69119 from LifeSpan Bioscience

Prices $415.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-AUTL1 / ATG4C Antibody - LS-C93849 from LifeSpan Bioscience

Prices $325.00
Sizes 500 µg
Host Sheep
Clonality Polyclonal

Anti-AUTL1 / ATG4C Antibody (aa175-224) - LS-C117073 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
ATG4C antibody LS-C117073 Western blot of 721_B cell lysate.

Anti-AUTL1 / ATG4C Antibody - LS-C156597 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Mouse
Clonality Monoclonal
ATG4C Antibody western blot of mouse heart tissue lysates (35 ug/lane). The ATG4C antibody detected the ATG4C protein (arrow).

Anti-AUTL1 / ATG4C Antibody (aa51-65) - LS-C188039 from LifeSpan Bioscience

Prices $420.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-AUTL1 / ATG4C Antibody (clone 287CT12.2.2, AP) - LS-C250143 from LifeSpan Bioscience

Prices $545.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 287CT12.2.2

Anti-AUTL1 / ATG4C Antibody (aa21-70) - LS-C119887 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
IHC of paraffin-embedded human liver carcinoma tissue, using ATG4C Antibody. The picture on the right is treated with the synthesized peptide.

Anti-AUTL1 / ATG4C Antibody (clone 287CT12.2.2, Biotin) - LS-C250144 from LifeSpan Bioscience

Prices $545.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 287CT12.2.2

Anti-AUTL1 / ATG4C Antibody - LS-C156596 from LifeSpan Bioscience

Prices $250.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot of ATG4C Antibody in HeLa cell line lysates (35 ug/lane). ATG4C (arrow) was detected using the purified Pab.

Anti-AUTL1 / ATG4C Antibody (clone 287CT12.2.2, APC) - LS-C250145 from LifeSpan Bioscience

Prices $545.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 287CT12.2.2

Anti-AUTL1 / ATG4C Antibody (clone 287CT12.2.2, FITC) - LS-C250146 from LifeSpan Bioscience

Prices $545.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 287CT12.2.2

Anti-AUTL1 / ATG4C Antibody (clone 287CT12.2.2, PE) - LS-C250148 from LifeSpan Bioscience

Prices $545.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 287CT12.2.2

Anti-AUTL1 / ATG4C Antibody (clone 287CT12.2.2, Azide-free, HRP) - LS-C250147 from LifeSpan Bioscience

Prices $545.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 287CT12.2.2
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