ATG4C

Gene Symbol	ATG4C
Entrez Gene	84938
Alt Symbol	APG4-C, APG4C, AUTL1, AUTL3
Species	Human
Gene Type	protein-coding
Description	autophagy related 4C, cysteine peptidase
Other Description	APG4 autophagy 4 homolog C|ATG4 autophagy related 4 homolog C|AUT-like 1, cysteine endopeptidase|AUT-like 3 cysteine endopeptidase|autophagin-3|autophagy-related cysteine endopeptidase 3|autophagy-related protein 4 homolog C|cysteine protease ATG4C
Swissprots	Q96DT6 A6NLR8 D3DQ58 Q96K04
Accessions	EAX06579 EAX06580 Q96DT6 AJ312234 CAC85556 AJ320169 CAC43939 AK027773 BAB55356 BC008395 BC018678 AAH18678 BC033024 AAH33024 BI518482 BM146035 BM720875 BQ777265 DB183325 DQ892482 ABM83408 DQ895693 ABM86619 XM_005271288 XP_005271345 XM_011542313 XP_011540615 XM_011542314 XP_011540616 NM_032852 NP_116241 NM_178221 NP_835739
Function	Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Is not essential for autophagy development under normal conditions but is required for a proper autophagic response under stressful conditions such as prolonged starvation (By similarity). Cleaves the C-terminal amino acid of ATG8 family proteins MAP1LC3 and GABARAPL2, to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Has also an activity of delipidating enzyme for the PE-conjugated forms. {ECO:0000250, ECO:0000269|PubMed:21177865}.
Subcellular Location	Cytoplasm {ECO:0000250}.
Tissue Specificity	Highly expressed in skeletal muscle, heart, liver and testis. {ECO:0000269|PubMed:12446702}.
Top Pathways	Regulation of autophagy

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SignalSilence ® Atg4C siRNA I - 6325 from Cell Signaling Technology Category siRNA Prices $249.00 Sizes 300 µl (3 nmol)

Atg4C CRISPR/Cas9 KO Plasmid (h) - sc-416600 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Atg4C HDR Plasmid (h) - sc-416600-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Atg4C Double Nickase Plasmid (h) - sc-416600-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Atg4C Double Nickase Plasmid (h2) - sc-416600-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Atg4C CRISPR Activation Plasmid (h) - sc-416600-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Atg4C CRISPR Activation Plasmid (h2) - sc-416600-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Atg4C Lentiviral Activation Particles (h) - sc-416600-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Atg4C Lentiviral Activation Particles (h2) - sc-416600-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Atg4C siRNA (h) - sc-78773 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Atg4C shRNA Plasmid (h) - sc-78773-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Atg4C shRNA (h) Lentiviral Particles - sc-78773-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

MISSION® esiRNA - EHU060781 from Sigma-Aldrich Category siRNA Prices $250.00 Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN3653 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3653 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR01855 from Sigma-Aldrich Category miRNA Prices $350.00 Sizes hutr01855

ATG4C siRNA (Human) - CRJ3709 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

ATG4C - MBS8214447 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human ATG4C (NM_178221.2) - SHH242138 from Creative biogene Category siRNA Species Reactivities Human

ATG4C shRNA Plasmid (Human) - CHJ3709 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

ATG4C miRNA 3'UTR clone - MiUTR3H-11810 from Creative biogene Species Reactivities Human

ATG4C miRNA 3'UTR clone - MiUTR3H-11811 from Creative biogene Species Reactivities Human

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