| Gene Symbol |
IRF8
|
| Entrez Gene |
3394
|
| Alt Symbol |
H-ICSBP, ICSBP, ICSBP1, IMD32A, IMD32B, IRF-8
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
interferon regulatory factor 8
|
| Other Description |
interferon consensus sequence binding protein 1
|
| Swissprots |
A0AV82 Q02556
|
| Accessions |
EAW95435 Q02556 AA232881 AI307662 AK313524 BAG36304 BC126247 AAI26248 BF110315 BG107396 BI835080 CB214983 M91196 AAB63813 XM_011523064 XP_011521366 NM_002163 NP_002154
|
| Function |
Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)). Plays a negative regulatory role in cells of the immune system. Involved in CD8(+) dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF8 and activation of genes (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:23166356}.
|
| Tissue Specificity |
Predominantly expressed in lymphoid tissues. {ECO:0000269|PubMed:1460054, ECO:0000269|PubMed:23166356}.
|
| Top Pathways |
Pertussis
|
