IRF8

Gene Symbol	IRF8
Entrez Gene	3394
Alt Symbol	H-ICSBP, ICSBP, ICSBP1, IMD32A, IMD32B, IRF-8
Species	Human
Gene Type	protein-coding
Description	interferon regulatory factor 8
Other Description	interferon consensus sequence binding protein 1
Swissprots	A0AV82 Q02556
Accessions	EAW95435 Q02556 AA232881 AI307662 AK313524 BAG36304 BC126247 AAI26248 BF110315 BG107396 BI835080 CB214983 M91196 AAB63813 XM_011523064 XP_011521366 NM_002163 NP_002154
Function	Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)). Plays a negative regulatory role in cells of the immune system. Involved in CD8(+) dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF8 and activation of genes (By similarity). {ECO:0000250}.
Subcellular Location	Nucleus {ECO:0000269|PubMed:23166356}.
Tissue Specificity	Predominantly expressed in lymphoid tissues. {ECO:0000269|PubMed:1460054, ECO:0000269|PubMed:23166356}.
Top Pathways	Pertussis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human IRF8 full length protein - ab131895 from Abcam Category Protein Source Wheat germ Species Human

Human IRF8 peptide - ab22947 from Abcam Category Peptide Species Human

Human IRF8 protein fragment - ab158720 from Abcam Category Protein Source Wheat germ Species Human

IRF8 peptide - ab106424 from Abcam Category Peptide

ICSBP / IRF8 Antibody Blocking Peptide - LS-E10877 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ICSBP / IRF8 Blocking Peptide - LS-E10878 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ICSBP / IRF8 Antibody Blocking Peptide - LS-E30095 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

ICSBP / IRF8 Antibody Blocking Peptide - LS-E7131 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ICSBP / IRF8 Antibody Blocking Peptide - LS-E7132 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ICSBP / IRF8 Antibody Blocking Peptide - LS-E25413 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human IRF8 Protein - H00003394-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human IRF8 Protein - H00003394-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

IRF8-Antibody-Center-Blocking-Peptide - BP2830c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

IRF8-Antibody-C-term-Blocking-Peptide - BP2830b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

IRF8 blocking peptide - GTX89895-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Rat, Bovine

IRF8 Blocking Peptide - 33R-7617 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

IRF8 Peptide - AC21-0241-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

IRF8 / ICSBP1 - H00003394-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

IRF8 / ICSBP1 - H00003394-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

IRF8 / ICSBP1 - H00003394-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

IRF8 / ICSBP1 - H00003394-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

IRF8 / ICSBP1 Control Peptide - AP30451CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

ICSBP1 Peptide - 45-073P from ProSci Category Peptide Prices $175.00 Sizes 100 µg Species Human

IRF8 Peptide - 3401P from ProSci Category Peptide Species Human

IRF8 fusion protein - ag19909 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

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