| Gene Symbol | IRF8 |
|---|---|
| Entrez Gene | 3394 |
| Alt Symbol | H-ICSBP, ICSBP, ICSBP1, IMD32A, IMD32B, IRF-8 |
| Species | Human |
| Gene Type | protein-coding |
| Description | interferon regulatory factor 8 |
| Other Description | interferon consensus sequence binding protein 1 |
| Swissprots | A0AV82 Q02556 |
| Accessions | EAW95435 Q02556 AA232881 AI307662 AK313524 BAG36304 BC126247 AAI26248 BF110315 BG107396 BI835080 CB214983 M91196 AAB63813 XM_011523064 XP_011521366 NM_002163 NP_002154 |
| Function | Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)). Plays a negative regulatory role in cells of the immune system. Involved in CD8(+) dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF8 and activation of genes (By similarity). {ECO:0000250}. |
| Subcellular Location | Nucleus {ECO:0000269|PubMed:23166356}. |
| Tissue Specificity | Predominantly expressed in lymphoid tissues. {ECO:0000269|PubMed:1460054, ECO:0000269|PubMed:23166356}. |
| Top Pathways | Pertussis |