IRF8

Gene Symbol IRF8
Entrez Gene 3394
Alt Symbol H-ICSBP, ICSBP, ICSBP1, IMD32A, IMD32B, IRF-8
Species Human
Gene Type protein-coding
Description interferon regulatory factor 8
Other Description interferon consensus sequence binding protein 1
Swissprots A0AV82 Q02556
Accessions EAW95435 Q02556 AA232881 AI307662 AK313524 BAG36304 BC126247 AAI26248 BF110315 BG107396 BI835080 CB214983 M91196 AAB63813 XM_011523064 XP_011521366 NM_002163 NP_002154
Function Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)). Plays a negative regulatory role in cells of the immune system. Involved in CD8(+) dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF8 and activation of genes (By similarity). {ECO:0000250}.
Subcellular Location Nucleus {ECO:0000269|PubMed:23166356}.
Tissue Specificity Predominantly expressed in lymphoid tissues. {ECO:0000269|PubMed:1460054, ECO:0000269|PubMed:23166356}.
Top Pathways Pertussis

IRF-8 (D20D8) Rabbit mAb - 5628 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D20D8
Western blot analysis of extracts from Raji and Jurkat cells, untreated or treated with Human Interferon-α1 (hIFN-α1) #8927 (10 ng/ml; overnight) using IRF-8 (D20D8) Rabbit mAb.

ICSBP (B-4) - sc-393676 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
ICSBP (B-4): sc-393676. Western blot analysis of ICSBP expression in non-transfected: sc-117752 (A) and mouse ICSBP transfected: sc-120937 (B) 293T whole cell lysates.

ICSBP (E-9) - sc-365042 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
ICSBP (E-9): sc-365042. Immunoperoxidase staining of formalin fixed, paraffin-embedded human lymph node tissue showing nuclear staining of subset of cells in germinal and non-germinal centers.

ICSBP (H-12) - sc-393955 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
ICSBP (H-12): sc-393955. Western blot analysis of ICSBP expression in non-transfected: sc-117752 (A) and mouse ICSBP transfected: sc-120937 (B) 293T whole cell lysates.

ICSBP (F-9) - sc-365041 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
ICSBP (F-9): sc-365041. Western blot analysis of ICSBP expression in IB4 (A) and NAMALWA (B) whole cell lysates.

ICSBP (S-15) - sc-79536 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

ICSBP (G-15) - sc-79535 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

ICSBP (H-70) - sc-13043 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
ICSBP (H-70): sc-13043. Western blot analysis of ICSBP expression in NAMALWA whole cell lysate.

ICSBP (C-19) - sc-6058 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
ICSBP (C-19): sc-6058. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human tonsil showing nuclear staining.

Anti-IRF8 antibody - ab93718 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-IRF8 antibody (ab93718) at 1 µg/mlLane 1 : Lymph node (Human) Tissue Lysate - adult normal tissue (ab29871)Lane 2 : Lymph node (Human) Tissue Lysate - adult normal tissue (ab29871) with immunizing peptide at 1 µg/mlLysates/proteins at 10 µg per lane.SecondaryGoat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97080) at 1/5000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-IRF8 antibody - ab135524 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-IRF8 antibody (ab135524) at 1/50 dilution + Jurkat cell line lysate at 35 µg

Anti-IRF8 antibody - ab85734 from Abcam

Prices $407.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
Anti-IRF8 antibody (ab85734) at 1 µg/ml + K562 lysate at 30 µg

Anti-IRF8 antibody - ab189837 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-IRF8 antibody (ab189837) at 1/500 dilutionLane 1 : HL-60 cell lysateLane 2 : THP-1 cell lysateLane 3 : Mouse spleen cell lysate

Anti-IRF8 antibody - ab189606 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-IRF8 antibody (ab189606) at 1/1000 dilutionLane 1 : Mouse thymus total cell extractLane 2 : HeLa total cell extract

Anti-IRF8 antibody - ab85059 from Abcam

Prices $370.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
Anti-IRF8 antibody (ab85059) at 1/500 dilution + Jurkat cell lysate

Anti-IRF8 antibody - ab3428 from Abcam

Prices $370.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-IRF8 antibody [mAbcam61750] - ab61750 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone mAbcam61750
All lanes : Anti-IRF8 antibody [mAbcam61750] (ab61750) at 10 µg/mlLane 1 : K562 (Human erythromyeloblastoid leukemia cell line) Whole Cell Lysate Lane 2 : K562 (Human erythromyeloblastoid leukemia cell line) Nuclear Lysate Lane 3 : Jurkat (Human T cell lymphoblast-like cell line) Whole Cell LysateLane 4 : Jurkat (Human T cell lymphoblast-like cell line) Nuclear Lysate (ab14844)Lysates/proteins at 20 µg per lane.SecondaryGoat polyclonal to Mouse IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-IRF8 antibody [mAbcam61750] - ab150224 from Abcam

Prices $359.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone mAbcam61750

Anti-IRF8 antibody [mAbcam61750] - BSA and Azide free - ab174642 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone mAbcam61750

Anti-ICSBP / IRF8 Antibody (C-Terminus) - LS-C137001 from LifeSpan Bioscience

Prices $255.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-ICSBP / IRF8 Antibody (clone D20D8) - LS-C183933 from LifeSpan Bioscience

Prices $435.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone D20D8

Anti-ICSBP / IRF8 Antibody (aa1-50) - LS-C290671 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-ICSBP / IRF8 Antibody (C-Terminus) - LS-C145527 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
IRF8 antibody LS-C145527 Western blot of 1 Cell lysate. Antibody concentration 1 ug/ml.

Anti-ICSBP / IRF8 Antibody (aa384-409) - LS-C97321 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Western blot of anti-IRF8 Antibody in HL60 cell line lysates (35 ug/lane). IRF8 (arrow) was detected using the purified antibody.

Anti-ICSBP / IRF8 Antibody (aa200-250) - LS-C290676 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
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