IRF8

Gene Symbol IRF8
Entrez Gene 3394
Alt Symbol H-ICSBP, ICSBP, ICSBP1, IMD32A, IMD32B, IRF-8
Species Human
Gene Type protein-coding
Description interferon regulatory factor 8
Other Description interferon consensus sequence binding protein 1
Swissprots A0AV82 Q02556
Accessions EAW95435 Q02556 AA232881 AI307662 AK313524 BAG36304 BC126247 AAI26248 BF110315 BG107396 BI835080 CB214983 M91196 AAB63813 XM_011523064 XP_011521366 NM_002163 NP_002154
Function Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)). Plays a negative regulatory role in cells of the immune system. Involved in CD8(+) dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF8 and activation of genes (By similarity). {ECO:0000250}.
Subcellular Location Nucleus {ECO:0000269|PubMed:23166356}.
Tissue Specificity Predominantly expressed in lymphoid tissues. {ECO:0000269|PubMed:1460054, ECO:0000269|PubMed:23166356}.
Top Pathways Pertussis

ICSBP CRISPR/Cas9 KO Plasmid (h) - sc-400774 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

ICSBP HDR Plasmid (h) - sc-400774-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ICSBP Double Nickase Plasmid (h) - sc-400774-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ICSBP Double Nickase Plasmid (h2) - sc-400774-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ICSBP CRISPR Activation Plasmid (h) - sc-400774-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

ICSBP CRISPR Activation Plasmid (h2) - sc-400774-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

ICSBP Lentiviral Activation Particles (h) - sc-400774-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ICSBP Lentiviral Activation Particles (h2) - sc-400774-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ICSBP siRNA (h) - sc-35630 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

ICSBP shRNA Plasmid (h) - sc-35630-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

ICSBP shRNA (h) Lentiviral Particles - sc-35630-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

IRF8 RNAi - H00003394-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

CompoZr® Knockout ZFN Kit - CKOZFN10769 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10769 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR09158 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr09158

IRF8 siRNA (Human) - CRH2305 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

IRF8 - MBS829476 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

Human IRF8 siRNA - orb262807 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

IRF8 shRNA Plasmid (Human) - CHH2305 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human
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