NR1D2

Gene Symbol	NR1D2
Entrez Gene	9975
Alt Symbol	BD73, EAR-1R, RVR
Species	Human
Gene Type	protein-coding
Description	nuclear receptor subfamily 1, group D, member 2
Other Description	V-erbA-related protein 1-related|nuclear receptor Rev-ErbA beta variant 1|nuclear receptor Rev-ErbA beta variant 2|nuclear receptor subfamily 1 group D member 2|orphan nuclear hormone receptor BD73|rev-erb alpha-related receptor|rev-erb-beta|rev-erba-alpha-related receptor
Swissprots	Q86XD4 Q14995 B2R8Q3 O00402
Accessions	EAW64340 EAW64341 Q14995 AB209091 BAD92328 AB307693 BAH02284 AK293273 BAG56802 AK301925 BAG63345 AK313464 BAG36250 BC015929 AAH15929 BC045613 AAH45613 BC070035 AAH70035 BX537786 CA312643 CA412377 CR457434 CAG33715 D16815 BAA20088 DR004486 HQ692830 ADZ17341 HQ692831 ADZ17342 L31785 AAA65937 XM_006713451 XP_006713514 NM_001145425 NP_001138897 NM_005126 NP_005117 NR_110524
Function	Transcriptional repressor which coordinates circadian rhythm and metabolic pathways in a heme-dependent manner. Integral component of the complex transcription machinery that governs circadian rhythmicity and forms a critical negative limb of the circadian clock by directly repressing the expression of core clock components ARNTL/BMAL1 and CLOCK. Also regulates genes involved in metabolic functions, including lipid metabolism and the inflammatory response. Acts as a receptor for heme which stimulates its interaction with the NCOR1/HDAC3 corepressor complex, enhancing transcriptional repression. Recognizes two classes of DNA response elements within the promoter of its target genes and can bind to DNA as either monomers or homodimers, depending on the nature of the response element. Binds as a monomer to a response element composed of the consensus half-site motif 5'-[A/G]GGTCA-3' preceded by an A/T-rich 5' sequence (RevRE), or as a homodimer to a direct repeat of the core motif spaced
Subcellular Location	Nucleus {ECO:0000255|PROSITE- ProRule:PRU00407, ECO:0000269|PubMed:17892483, ECO:0000269|PubMed:17996965}.
Tissue Specificity	Widely expressed. Expressed at high levels in the liver, adipose tissue, skeletal muscle and brain. Expression oscillates diurnally in the suprachiasmatic nucleus (SCN) of the hypothalamus as well as in peripheral tissues.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Rev-erbβ (C-16) - sc-47621 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Rev-erbβ (C-14) - sc-47620 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Rev-erbβ (H-47) - sc-134546 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

Rev-erbβ (QK-6) - sc-100911 from Santa Cruz Biotechnology Prices $295.00 Sizes 100 µg/ml Host Mouse Clonality Monoclonal

Anti-NR1D2 antibody - ab56913 from Abcam Prices $370.00 Sizes 100 µg Host Mouse Clonality Monoclonal

Anti-NR1D2 antibody - ab155764 from Abcam Prices $370.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-NR1D2 antibody - ab188791 from Abcam Prices $407.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-NR1D2 antibody - ab123552 from Abcam Prices $370.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-NR1D2 antibody - ab188076 from Abcam Prices $443.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-NR1D2 antibody [H2729] - ab41940 from Abcam Prices $370.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone H2729

Anti-NR1D2 Antibody (aa503-552) - LS-C109821 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-NR1D2 Antibody (aa265-294) - LS-C323431 from LifeSpan Bioscience Prices $435.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-NR1D2 Antibody (aa1-580, Azide-free) - LS-C328065 from LifeSpan Bioscience Host Mouse Clonality Monoclonal

Anti-NR1D2 Antibody (aa1-294, clone 5E10) - LS-C339947 from LifeSpan Bioscience Prices $325.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 5E10

Anti-NR1D2 Antibody (aa1-294, clone 3D4) - LS-C340021 from LifeSpan Bioscience Prices $325.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 3D4

Anti-NR1D2 Antibody (aa1-294, clone 5C6) - LS-C339946 from LifeSpan Bioscience Prices $325.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 5C6

Anti-NR1D2 Antibody (aa1-294, clone 4G1) - LS-C339948 from LifeSpan Bioscience Prices $325.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 4G1

Anti-NR1D2 Antibody (aa266-294) - LS-C162984 from LifeSpan Bioscience Prices $295.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-NR1D2 Antibody (Ligand-binding Domain) IHC-plus™ - LS-A2459 from LifeSpan Bioscience Prices $395.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-NR1D2 Antibody (Internal) IHC-plus™ - LS-A5645 from LifeSpan Bioscience Prices $395.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-NR1D2 Antibody (N-Terminus) IHC-plus™ - LS-A8043 from LifeSpan Bioscience Prices $395.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-NR1D2 Antibody (C-Terminus) - LS-C31295 from LifeSpan Bioscience Prices $325.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-NR1D2 Antibody (aa265-294, AP) - LS-C264694 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-NR1D2 Antibody (aa265-294, APC) - LS-C264696 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-NR1D2 Antibody (aa265-294, Biotin) - LS-C264697 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

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