NR1D2

Gene Symbol NR1D2
Entrez Gene 9975
Alt Symbol BD73, EAR-1R, RVR
Species Human
Gene Type protein-coding
Description nuclear receptor subfamily 1, group D, member 2
Other Description V-erbA-related protein 1-related|nuclear receptor Rev-ErbA beta variant 1|nuclear receptor Rev-ErbA beta variant 2|nuclear receptor subfamily 1 group D member 2|orphan nuclear hormone receptor BD73|rev-erb alpha-related receptor|rev-erb-beta|rev-erba-alpha-related receptor
Swissprots Q86XD4 Q14995 B2R8Q3 O00402
Accessions EAW64340 EAW64341 Q14995 AB209091 BAD92328 AB307693 BAH02284 AK293273 BAG56802 AK301925 BAG63345 AK313464 BAG36250 BC015929 AAH15929 BC045613 AAH45613 BC070035 AAH70035 BX537786 CA312643 CA412377 CR457434 CAG33715 D16815 BAA20088 DR004486 HQ692830 ADZ17341 HQ692831 ADZ17342 L31785 AAA65937 XM_006713451 XP_006713514 NM_001145425 NP_001138897 NM_005126 NP_005117 NR_110524
Function Transcriptional repressor which coordinates circadian rhythm and metabolic pathways in a heme-dependent manner. Integral component of the complex transcription machinery that governs circadian rhythmicity and forms a critical negative limb of the circadian clock by directly repressing the expression of core clock components ARNTL/BMAL1 and CLOCK. Also regulates genes involved in metabolic functions, including lipid metabolism and the inflammatory response. Acts as a receptor for heme which stimulates its interaction with the NCOR1/HDAC3 corepressor complex, enhancing transcriptional repression. Recognizes two classes of DNA response elements within the promoter of its target genes and can bind to DNA as either monomers or homodimers, depending on the nature of the response element. Binds as a monomer to a response element composed of the consensus half-site motif 5'-[A/G]GGTCA-3' preceded by an A/T-rich 5' sequence (RevRE), or as a homodimer to a direct repeat of the core motif spaced
Subcellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00407, ECO:0000269|PubMed:17892483, ECO:0000269|PubMed:17996965}.
Tissue Specificity Widely expressed. Expressed at high levels in the liver, adipose tissue, skeletal muscle and brain. Expression oscillates diurnally in the suprachiasmatic nucleus (SCN) of the hypothalamus as well as in peripheral tissues.

Human-NR1D2-cDNA-Clone - DC08844 from Abgent, a WuXi AppTec company

Prices $550.80
Sizes 10 µg
Species Human
Accession BC070035

NR1D2 - MBS1271942 from MyBioSource

Prices $175.00
Sizes 10ug plasmid + 200ul glycerol stock
Species Human
Accession BC070035

Human NR1D2 cDNA clone(NM_001145425.1) - CDFH012759 from Creative Biomart

Species Human
Accession NM_001145425.1

Human NR1D2 ORF Clone(NM_001145425.1) - CDCR352826 from Creative Biomart

Species Human
Accession NM_001145425.1

Human NR1D2 ORF Clone(NM_001145425.1) - CDCR352830 from Creative Biomart

Species Human
Accession NM_001145425.1

Human NR1D2 ORF clone (NM_001145425.1) - CDCL139631 from Creative biogene

Species Human

Human NR1D2 ORF Clone (BC070035) - CDCS408515 from Creative biogene

Species Human
Accession B4DXD3

Human NR1D2 cDNA Clone(NM_001145425.1) - CDFH012759 from Creative biogene

Species Human
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