NR1D2

Gene Symbol	NR1D2
Entrez Gene	9975
Alt Symbol	BD73, EAR-1R, RVR
Species	Human
Gene Type	protein-coding
Description	nuclear receptor subfamily 1, group D, member 2
Other Description	V-erbA-related protein 1-related|nuclear receptor Rev-ErbA beta variant 1|nuclear receptor Rev-ErbA beta variant 2|nuclear receptor subfamily 1 group D member 2|orphan nuclear hormone receptor BD73|rev-erb alpha-related receptor|rev-erb-beta|rev-erba-alpha-related receptor
Swissprots	Q86XD4 Q14995 B2R8Q3 O00402
Accessions	EAW64340 EAW64341 Q14995 AB209091 BAD92328 AB307693 BAH02284 AK293273 BAG56802 AK301925 BAG63345 AK313464 BAG36250 BC015929 AAH15929 BC045613 AAH45613 BC070035 AAH70035 BX537786 CA312643 CA412377 CR457434 CAG33715 D16815 BAA20088 DR004486 HQ692830 ADZ17341 HQ692831 ADZ17342 L31785 AAA65937 XM_006713451 XP_006713514 NM_001145425 NP_001138897 NM_005126 NP_005117 NR_110524
Function	Transcriptional repressor which coordinates circadian rhythm and metabolic pathways in a heme-dependent manner. Integral component of the complex transcription machinery that governs circadian rhythmicity and forms a critical negative limb of the circadian clock by directly repressing the expression of core clock components ARNTL/BMAL1 and CLOCK. Also regulates genes involved in metabolic functions, including lipid metabolism and the inflammatory response. Acts as a receptor for heme which stimulates its interaction with the NCOR1/HDAC3 corepressor complex, enhancing transcriptional repression. Recognizes two classes of DNA response elements within the promoter of its target genes and can bind to DNA as either monomers or homodimers, depending on the nature of the response element. Binds as a monomer to a response element composed of the consensus half-site motif 5'-[A/G]GGTCA-3' preceded by an A/T-rich 5' sequence (RevRE), or as a homodimer to a direct repeat of the core motif spaced
Subcellular Location	Nucleus {ECO:0000255|PROSITE- ProRule:PRU00407, ECO:0000269|PubMed:17892483, ECO:0000269|PubMed:17996965}.
Tissue Specificity	Widely expressed. Expressed at high levels in the liver, adipose tissue, skeletal muscle and brain. Expression oscillates diurnally in the suprachiasmatic nucleus (SCN) of the hypothalamus as well as in peripheral tissues.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human NR1D2 full length protein - ab82085 from Abcam Category Protein Prices $302.00 Sizes 5 µg Source Baculovirus Species Human

Human NR1D2 full length protein - ab153033 from Abcam Category Protein Source Wheat germ Species Human

NR1D2 Antibody Blocking Peptide - LS-E3652 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

NR1D2 Antibody Blocking Peptide - LS-E29085 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

NR1D2 Antibody Blocking Peptide - LS-E13876 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

NR1D2 Antibody Blocking Peptide - LS-E28558 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

NR1D2 Antibody Blocking Peptide - LS-E29318 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

NR1D2 Antibody Blocking Peptide - LS-E29319 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

Recombinant Human Rev-erb beta/NR1D2 Protein - H00009975-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

NR1D2-Antibody-Center-Blocking-Peptide - BP14855c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

NR1D2 - H00009975-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

NR1D2 - H00009975-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

NR1D2 fusion protein - ag4881 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human Nuclear R eceptor Subfamily 1, Group D, Member 2 - NRID2-1150H from Creative Biomart Category Protein Source Sf9 insect cells .

Recombinant Human NR1D2 - NR1D2-30452TH from Creative Biomart Category Protein

Recombinant Human NR1D2, His-tagged - NR1D2-8488H from Creative Biomart Category Protein Source Sf21 Cells Species Human

Recombinant Nuclear Receptor Subfamily 1, Group D, Member 2 (NR1D2) - RPD946Ra01 from Uscn Life Science Inc. Category Protein Source E.coli Species Rat

Recombinant Human Nuclear receptor subfamily 1 group D member 2(NR1D2) - CSB-YP623948HU CSB-EP623948HU CSB-BP623948HU CSB-MP623948HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

NR1D2 (transcript variant 1) - TP306338 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

Recombinant Human Nuclear Receptor subfamily 1 group D member 2 His - CSI14002 from Cell Science Prices $840.00 Sizes 5 μg Species Human

Rev-erb beta/NR1D2 Recombinant Protein Antigen - NBP2-47306PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

NR1D2 Peptide, Human - M34GP10586H from Creative Peptides Category Peptide Source Synthetic. Species Human

Rev-erb beta/NR1D2 Recombinant Protein Antigen - NBP2-56141PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

Nuclear receptor subfamily 1 group D member 2 (NR1D2), Recombinant Protein - MBS1348618 from MyBioSource Category Protein Prices $1,380.00, $1,380.00, $1,595.00, $1,595.00, $2,295.00, $2,295.00, $2,760.00, $2,760.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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