NR1D2

Gene Symbol	NR1D2
Entrez Gene	9975
Alt Symbol	BD73, EAR-1R, RVR
Species	Human
Gene Type	protein-coding
Description	nuclear receptor subfamily 1, group D, member 2
Other Description	V-erbA-related protein 1-related|nuclear receptor Rev-ErbA beta variant 1|nuclear receptor Rev-ErbA beta variant 2|nuclear receptor subfamily 1 group D member 2|orphan nuclear hormone receptor BD73|rev-erb alpha-related receptor|rev-erb-beta|rev-erba-alpha-related receptor
Swissprots	Q86XD4 Q14995 B2R8Q3 O00402
Accessions	EAW64340 EAW64341 Q14995 AB209091 BAD92328 AB307693 BAH02284 AK293273 BAG56802 AK301925 BAG63345 AK313464 BAG36250 BC015929 AAH15929 BC045613 AAH45613 BC070035 AAH70035 BX537786 CA312643 CA412377 CR457434 CAG33715 D16815 BAA20088 DR004486 HQ692830 ADZ17341 HQ692831 ADZ17342 L31785 AAA65937 XM_006713451 XP_006713514 NM_001145425 NP_001138897 NM_005126 NP_005117 NR_110524
Function	Transcriptional repressor which coordinates circadian rhythm and metabolic pathways in a heme-dependent manner. Integral component of the complex transcription machinery that governs circadian rhythmicity and forms a critical negative limb of the circadian clock by directly repressing the expression of core clock components ARNTL/BMAL1 and CLOCK. Also regulates genes involved in metabolic functions, including lipid metabolism and the inflammatory response. Acts as a receptor for heme which stimulates its interaction with the NCOR1/HDAC3 corepressor complex, enhancing transcriptional repression. Recognizes two classes of DNA response elements within the promoter of its target genes and can bind to DNA as either monomers or homodimers, depending on the nature of the response element. Binds as a monomer to a response element composed of the consensus half-site motif 5'-[A/G]GGTCA-3' preceded by an A/T-rich 5' sequence (RevRE), or as a homodimer to a direct repeat of the core motif spaced
Subcellular Location	Nucleus {ECO:0000255|PROSITE- ProRule:PRU00407, ECO:0000269|PubMed:17892483, ECO:0000269|PubMed:17996965}.
Tissue Specificity	Widely expressed. Expressed at high levels in the liver, adipose tissue, skeletal muscle and brain. Expression oscillates diurnally in the suprachiasmatic nucleus (SCN) of the hypothalamus as well as in peripheral tissues.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Rev-erbβ siRNA (h) - sc-61456 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Rev-erbβ shRNA Plasmid (h) - sc-61456-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Rev-erbβ shRNA (h) Lentiviral Particles - sc-61456-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Rev-erb beta/NR1D2 RNAi - H00009975-R01V from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

Rev-erb beta/NR1D2 RNAi - H00009975-R01 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU048441 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN15485 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND15485 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

NR1D2 siRNA (Human) - CRH6711 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human NR1D2 (NM_005126.4) - SHH354648 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human NR1D2(NM_001145425.1) - SHR019232 from Creative biogene Category siRNA Species Reactivities Human

Human NR1D2 siRNA - orb267213 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

NR1D2 shRNA Plasmid (Human) - CHH6711 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

NR1D2 miRNA 3'UTR clone - MiUTR1H-06892 from Creative biogene Species Reactivities Human

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