CYP51A1

Gene Symbol CYP51A1
Entrez Gene 1595
Alt Symbol CP51, CYP51, CYPL1, LDM, P450-14DM, P450L1
Species Human
Gene Type protein-coding
Description cytochrome P450, family 51, subfamily A, polypeptide 1
Other Description CYPLI|cytochrome P450 51A1|cytochrome P450, 51 (lanosterol 14-alpha-demethylase)|cytochrome P450-14DM|cytochrome P45014DM|cytochrome P450LI|lanosterol 14-alpha demethylase|lanosterol 14-alpha-demethylase|sterol 14-alpha demethylase
Swissprots Q99868 B4DJ55 O00772 B2RAI4 Q16850 Q8N1A8 A4D1F8 O00770 Q16784
Accessions AAB46356 AAC50951 EAL24154 EAW76858 EAW76859 Q16850 AK295932 BAG58717 AK314205 BAG36881 BC018429 AAH18429 BC032322 AAH32322 D55653 BAA09512 DA349400 DC376300 DQ891311 ABM82237 DQ894495 ABM85421 U23942 AAB39951 NM_000786 NP_000777 NM_001146152 NP_001139624
Function Catalyzes C14-demethylation of lanosterol; it transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol. {ECO:0000269|PubMed:20149798}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000305}. Microsome membrane {ECO:0000305}.
Tissue Specificity Ubiquitously expressed with highest levels in testis, ovary, adrenal, prostate, liver, kidney and lung. {ECO:0000269|PubMed:8619637}.
Top Pathways Steroid biosynthesis

CYP51A1 (C-13) - sc-160263 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
CYP51A1 (C-13): sc-160263. Western blot analysis of CYP51A1 expression in THP-1 whole cell lysate.

CYP51A1 (E-14) - sc-160264 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-CYP51A1 antibody - ab135723 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-CYP51A1 antibody (ab135723) + HL60 cell lysate at 35 µg

Anti-CYP51A1 antibody - ab126051 from Abcam

Prices $370.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-CYP51A1 antibody (ab126051) at 1/1000 dilution + THP1 whole cell lysate at 30 µg

Anti-CYP51A1 antibody - C-terminal - ab175863 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-CYP51A1 antibody - C-terminal (ab175863) at 1/1000 dilution + HL60 cell lysate at 35 µg

Anti-CYP51A1 / CYP51 Antibody - LS-C341996 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CYP51A1 / CYP51 Antibody (aa112-161) - LS-C135728 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
CYP51A1 antibody LS-C135728 Western blot of HeLa lysate.

Anti-CYP51A1 / CYP51 Antibody - LS-C155291 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
Sample (30 ug of whole cell lysate) A: THP-1 7.5% SDS PAGE CYP51A1 antibody diluted at 1:1000

Anti-CYP51A1 / CYP51 Antibody (aa474-503) - LS-C167242 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin-embedded human prostate carcinoma reacted with CYP51A1 Antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

Anti-CYP51A1 / CYP51 Antibody - LS-C334588 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
Immunofluorescence analysis of MCF-7 cell using CYP51A1 antibody. Blue: DAPI for nuclear staining.

Anti-CYP51A1 / CYP51 Antibody (aa257-287) - LS-C167243 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin-embedded human prostate carcinoma reacted with CYP51A1 Antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

CYP51A1 Antibody - NBP1-79790 from Novus Biologicals

Prices $139.00, $329.00
Sizes 20 µl, 100 µl
Host Rabbit
Clonality Polyclonal

CYP51A1 Antibody - NBP2-16071 from Novus Biologicals

Prices $349.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: CYP51A1 Antibody [NBP2-16071] - Sample (30 ug of whole cell lysate) A: THP-1 7. 5% SDS PAGE gel, diluted at 1:1000.

CYP51A1 Antibody - H00001595-A01 from Novus Biologicals

Prices $269.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal

Anti-CYP51A1 (495-509) antibody produced in rabbit - C8873 from Sigma-Aldrich

Prices $309.50
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
<B>Immunofluorescence</B><BR/>Anti-CYP51A1 (495-509): <B>Cat. No. C8873</B>: Immunofluorescence of HUVEC cells using CYP51A1 (495-509), Cat. No. C8873 (red) at a 1:50 dilution, taken at 40× magnification and nuclear staining with Hoescht 33342 (blue).Yale HTCB IF procedure used. Images may have been adjusted to improve viewing quality. If you would like the original image, please send a request to protocols@sial.com

Anti-CYP51A1 antibody produced in rabbit - SAB2107501 from Sigma-Aldrich

Prices $341.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-CYP51A1: <B>Cat. No. SAB2107501</B>: Western blot analysis of CYP51A1 with CYP51A1 (cytochrome P450, family 51, subfamily A, polypeptide 1) antibody against the N terminal of CYP51A1 (50 μg) antibody at 0.25 μg/mL.

ANTI-CYP51A1 (C-TERM) antibody produced in rabbit - SAB1303650 from Sigma-Aldrich

Prices $326.50
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>CYP51A1 (C-term): <B>Cat. No. SAB1303650</B>: CYP51A1 in Human prostata carcinoma tissue with CYP51A1 antibody (C-term) at 5 μg/mL.

Anti-CYP51A1 antibody produced in rabbit - HPA041325 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-CYP51A1: <B>Cat. No. HPA041325</B>: Immunohistochemical staining of human testis shows strong cytoplasmic positivity in Leydig cells.

Anti-CYP51A1 antibody produced in rabbit - HPA043508 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-CYP51A1: <B>Cat. No. HPA043508</B>: Immunohistochemical staining of human testis shows strong cytoplasmic positivity in Leydig cells.

ANTI-CYP51A1 (CENTER) antibody produced in rabbit - SAB1303148 from Sigma-Aldrich

Prices $326.50
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>CYP51A1 (Center): <B>Cat. No. SAB1303148</B>: CYP51A1 in Human prostata carcinoma tissue with CYP51A1 antibody (Center) at 5 μg/mL.

CYP51A1 antibody - N-terminal region (ARP60153_P050) - ARP60153_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

CYP51A1-Antibody-Center - AP8874c from Abgent, a WuXi AppTec company

Prices $99.00, $295.00
Sizes 80 µl, 400 µl
Host Rabbit
Clonality Polyclonal
Western blot analysis of lysate from LNCap cell line, using CYP51A1 Antibody (Center)(Cat. #AP8874c). AP8874c was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody. Lysate at 35ug.

CYP51A1-Antibody-C-term - AP8874b from Abgent, a WuXi AppTec company

Prices $99.00, $295.00
Sizes 80 µl, 400 µl
Host Rabbit
Clonality Polyclonal
Western blot analysis of CYP51A1 Antibody (C-term) (Cat. #AP8874b) in HL-60 cell line lysates (35ug/lane). CYP51A1 (arrow) was detected using the purified Pab.

CYP51A1 Antibody - C-terminal region (OAAB05468) - OAAB05468 from Aviva Systems Biology

Prices $289.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal

CYP51A1 Antibody - middle region (OAAB05469) - OAAB05469 from Aviva Systems Biology

Prices $289.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
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