SNX1

Gene Symbol SNX1
Entrez Gene 6642
Alt Symbol HsT17379, VPS5
Species Human
Gene Type protein-coding
Description sorting nexin 1
Other Description sorting nexin 1A|sorting nexin-1
Swissprots O60750 H0Y2M5 Q13596 Q6ZRJ8 A8K6T7 O60751 A6NM19
Accessions EAW77663 EAW77664 EAW77665 EAW77666 Q13596 AB209013 BAD92250 AF065483 AAC17182 AF065484 AAC17183 AF131792 AK128179 BAC87312 AK222561 BAD96281 AK222793 BAD96513 AK291752 BAF84441 AK310618 AL050148 AU279817 BC000357 AAH00357 BQ935515 BT006983 AAP35629 BX108623 DB455188 DQ890751 ABM81677 DQ893918 ABM84844 EF491792 U53225 AAA98672 XM_005254611 XP_005254668 NM_001242933 NP_001229862 NM_003099 NP_003090 NM_148955 NP_683758 NM_152826
Function Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3- phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (PubMed:12198132). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Can sense membrane curvature and has in vitro vesicle- to-membrane remodeling activity (PubMed:19816406, PubMed:23085988). Involved in retrograde endosome-to-TGN transport of lysosomal enzyme receptors (IGF2R, M6PR and SORT1) and Shiginella dysenteria toxin stxB. Plays a role in targeting ligand-activated EGFR to the lysosomes for degradation after endoc
Subcellular Location Endosome membrane {ECO:0000269|PubMed:15498486, ECO:0000269|PubMed:18088323}; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus, trans-Golgi network membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Early endosome membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, lamellipodium {ECO:0000269|PubMed:20604901}. Note=Enriched on tubular elements of the early endosome membrane. Binds preferentially to highly curved membranes enriched in phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (PubMed:15498486). Colocalized with SORT1 to tubular endosomal membrane structures called endosome-to-TGN transport carriers (ETCs) which are budding from early endosome vacuoles just before maturing into late endosome vacuoles (PubMed:18088323). Colocalizes with DNAJC13 and Shiginella dysenteria toxin stxB on early endosomes (PubMed:19874558). Colocalized with F-actin at t

SNX1 (B-8) - sc-376376 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
SNX1 (B-8): sc-376376. Western blot analysis of SNX1 expression in KNRK whole cell lysate.

SNX1 (H-115) - sc-292684 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
SNX1 (H-115): sc-292684. Western blot analysis of SNX1 expression in 293T (A) and MIA PaCa-2 (B) whole cell lysates.

SNX1 (E-16) - sc-10612 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
SNX1 (E-16): sc-10612. Western blot analysis of SNX1 expression in rat spleen extract.

SNX1 (T-19) - sc-10609 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
SNX1 (T-19): sc-10609. Western blot analysis of SNX1 expression in KNRK whole cell lysate.

SNX1 (51) - sc-136247 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/0.5 ml
Host Mouse
Clonality Monoclonal
SNX1 (51): sc-136247. Immunofluorescence staining of HeLa cells showing cytoplasmic localization.

Anti-SNX1 antibody - ab55776 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
SNX1 antibody (ab55776) used in immunohistochemistry at 3ug/ml on formalin fixed and paraffin embedded human tonsil.

Anti-SNX1 antibody [EPR7178] - ab134126 from Abcam

Prices $313.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR7178
ab134126 stained HeLa cells. The cells were 4% formaldehyde fixed for 10 minutes at room temperature and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1hour at room temperature to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody (ab134126 at 1/100 dilution) overnight at +4°C. The secondary antibody (pseudo-colored green) was Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) preadsorbed (ab150081) used at a 1/1000 dilution for 1hour at room temperature. Alexa Fluor® 594 WGA was used to label plasma membranes (pseudo-colored red) at a 1/200 dilution for 1hour at room temperature. DAPI was used to stain the cell nuclei (pseudo-colored blue) at a concentration of 1.43µM for 1hour at room temperature.

Anti-SNX1 Antibody (aa122-135) IHC-plus™ - LS-B9210 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
Anti-SNX1 antibody IHC staining of human uterus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-SNX1 Antibody (clone 6H1) - LS-C133443 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 6H1
Immunoperoxidase of monoclonal antibody to SNX1 on formalin-fixed paraffin-embedded human tonsil. [antibody concentration 3 ug/ml]

Anti-SNX1 Antibody (aa44-93) IHC-plus™ - LS-B12035 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Human Lung: Formalin-Fixed, Paraffin-Embedded (FFPE)

Anti-SNX1 Antibody - LS-C89157 from LifeSpan Bioscience

Prices $575.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-SNX1 Antibody - LS-C109250 from LifeSpan Bioscience

Prices $385.00
Sizes 1 ml
Host Sheep
Clonality Polyclonal

Anti-SNX1 Antibody (Biotin) - LS-C109252 from LifeSpan Bioscience

Prices $405.00
Sizes 1 mg
Host Sheep
Clonality Polyclonal

Anti-SNX1 Antibody (FITC) - LS-C109253 from LifeSpan Bioscience

Prices $405.00
Sizes 1 mg
Host Sheep
Clonality Polyclonal

Anti-SNX1 Antibody - LS-C109251 from LifeSpan Bioscience

Prices $385.00
Sizes 1 mg
Host Sheep
Clonality Polyclonal

Anti-SNX1 Antibody - LS-C109254 from LifeSpan Bioscience

Prices $335.00, $1,035.00
Sizes 200 µg, 1 mg
Host Sheep
Clonality Polyclonal

Anti-SNX1 Antibody (aa426-455, AP) - LS-C217670 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SNX1 Antibody (aa426-455, APC) - LS-C217671 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SNX1 Antibody (aa426-455, Biotin) - LS-C217672 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SNX1 Antibody (aa426-455, Azide-free, HRP) - LS-C217673 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SNX1 Antibody (aa426-455, FITC) - LS-C217674 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SNX1 Antibody (aa426-455, PE) - LS-C217675 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SNX1 Antibody (aa458-503) - LS-C313960 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SNX1 Antibody (aa425-455) - LS-C325249 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SNX6 Antibody (aa166-276) - LS-C328701 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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