SNX1

Gene Symbol SNX1
Entrez Gene 6642
Alt Symbol HsT17379, VPS5
Species Human
Gene Type protein-coding
Description sorting nexin 1
Other Description sorting nexin 1A|sorting nexin-1
Swissprots O60750 H0Y2M5 Q13596 Q6ZRJ8 A8K6T7 O60751 A6NM19
Accessions EAW77663 EAW77664 EAW77665 EAW77666 Q13596 AB209013 BAD92250 AF065483 AAC17182 AF065484 AAC17183 AF131792 AK128179 BAC87312 AK222561 BAD96281 AK222793 BAD96513 AK291752 BAF84441 AK310618 AL050148 AU279817 BC000357 AAH00357 BQ935515 BT006983 AAP35629 BX108623 DB455188 DQ890751 ABM81677 DQ893918 ABM84844 EF491792 U53225 AAA98672 XM_005254611 XP_005254668 NM_001242933 NP_001229862 NM_003099 NP_003090 NM_148955 NP_683758 NM_152826
Function Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3- phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (PubMed:12198132). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Can sense membrane curvature and has in vitro vesicle- to-membrane remodeling activity (PubMed:19816406, PubMed:23085988). Involved in retrograde endosome-to-TGN transport of lysosomal enzyme receptors (IGF2R, M6PR and SORT1) and Shiginella dysenteria toxin stxB. Plays a role in targeting ligand-activated EGFR to the lysosomes for degradation after endoc
Subcellular Location Endosome membrane {ECO:0000269|PubMed:15498486, ECO:0000269|PubMed:18088323}; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus, trans-Golgi network membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Early endosome membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, lamellipodium {ECO:0000269|PubMed:20604901}. Note=Enriched on tubular elements of the early endosome membrane. Binds preferentially to highly curved membranes enriched in phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (PubMed:15498486). Colocalized with SORT1 to tubular endosomal membrane structures called endosome-to-TGN transport carriers (ETCs) which are budding from early endosome vacuoles just before maturing into late endosome vacuoles (PubMed:18088323). Colocalizes with DNAJC13 and Shiginella dysenteria toxin stxB on early endosomes (PubMed:19874558). Colocalized with F-actin at t

SNX1 CRISPR/Cas9 KO Plasmid (h) - sc-404470 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

SNX1 HDR Plasmid (h) - sc-404470-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SNX1 Double Nickase Plasmid (h) - sc-404470-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SNX1 Double Nickase Plasmid (h2) - sc-404470-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SNX1 CRISPR Activation Plasmid (h) - sc-404470-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

SNX1 CRISPR Activation Plasmid (h2) - sc-404470-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

SNX1 Lentiviral Activation Particles (h) - sc-404470-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SNX1 Lentiviral Activation Particles (h2) - sc-404470-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SNX1 siRNA (h) - sc-41345 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

SNX1 shRNA Plasmid (h) - sc-41345-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

SNX1 shRNA (h) Lentiviral Particles - sc-41345-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

SNX1 RNAi - H00006642-R01V from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

SNX1 RNAi - H00006642-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

SNX1 RNAi - H00006642-R03 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

SNX1 RNAi - H00006642-R02 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU094091 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

MISSION® esiRNA - EHU100371 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

MISSION® esiRNA - EHU088541 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

MISSION® esiRNA - EHU140471 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN20287 from Sigma-Aldrich

Category ZFN Kit

SNX1 siRNA (Human) - CRH4523 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

SNX1 - MBS8206212 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human SNX1 (NM_003099.4) - SHH414548 from Creative biogene

Category siRNA
Species Reactivities Human

SNX1 shRNA Plasmid (Human) - CHH4523 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human
Search more