SNX1

Gene Symbol	SNX1
Entrez Gene	6642
Alt Symbol	HsT17379, VPS5
Species	Human
Gene Type	protein-coding
Description	sorting nexin 1
Other Description	sorting nexin 1A|sorting nexin-1
Swissprots	O60750 H0Y2M5 Q13596 Q6ZRJ8 A8K6T7 O60751 A6NM19
Accessions	EAW77663 EAW77664 EAW77665 EAW77666 Q13596 AB209013 BAD92250 AF065483 AAC17182 AF065484 AAC17183 AF131792 AK128179 BAC87312 AK222561 BAD96281 AK222793 BAD96513 AK291752 BAF84441 AK310618 AL050148 AU279817 BC000357 AAH00357 BQ935515 BT006983 AAP35629 BX108623 DB455188 DQ890751 ABM81677 DQ893918 ABM84844 EF491792 U53225 AAA98672 XM_005254611 XP_005254668 NM_001242933 NP_001229862 NM_003099 NP_003090 NM_148955 NP_683758 NM_152826
Function	Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3- phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (PubMed:12198132). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Can sense membrane curvature and has in vitro vesicle- to-membrane remodeling activity (PubMed:19816406, PubMed:23085988). Involved in retrograde endosome-to-TGN transport of lysosomal enzyme receptors (IGF2R, M6PR and SORT1) and Shiginella dysenteria toxin stxB. Plays a role in targeting ligand-activated EGFR to the lysosomes for degradation after endoc
Subcellular Location	Endosome membrane {ECO:0000269|PubMed:15498486, ECO:0000269|PubMed:18088323}; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus, trans-Golgi network membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Early endosome membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, lamellipodium {ECO:0000269|PubMed:20604901}. Note=Enriched on tubular elements of the early endosome membrane. Binds preferentially to highly curved membranes enriched in phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (PubMed:15498486). Colocalized with SORT1 to tubular endosomal membrane structures called endosome-to-TGN transport carriers (ETCs) which are budding from early endosome vacuoles just before maturing into late endosome vacuoles (PubMed:18088323). Colocalizes with DNAJC13 and Shiginella dysenteria toxin stxB on early endosomes (PubMed:19874558). Colocalized with F-actin at t

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human SNX1 full length protein - ab197545 from Abcam Category Protein Source Wheat germ Species Human

Human SNX1 protein fragment - ab101061 from Abcam Category Protein Source E. coli Species Human

SNX1 Antibody Blocking Peptide - LS-E2919 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SNX1 Antibody Blocking Peptide - LS-E27256 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SNX1 Antibody Blocking Peptide - LS-E23351 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SNX1 Recombinant Protein - H00006642-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

SNX1 Partial Recombinant Protein - H00006642-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human SNX1 Protein - NBP1-48347 from Novus Biologicals Category Protein Prices $269.00, $729.00 Sizes 10 µg, 50 µg Source E.coli Species Human

SNX1-Antibody-C-term-Blocking-peptide - BP14044b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

SNX1 blocking peptide - GTX88278-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog, Rat, Bovine

SNX1 Protein (OPPA02476) - OPPA02476 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 1 µg Source E. Coli

Human SNX1 protein - orb81375 from Biorbyt Category Protein Prices $170.00, $289.00, $1,139.00 Sizes 1 μg, 5 μg, 50 μg Species Human

SNX1 protein (His tag) - 80R-1459 from Fitzgerald Category Protein Prices $255.00 Sizes 10 µg Source E.coli

SNX1 Blocking Peptide - abx063285 from Abbexa Category Peptide Species Human, Mouse, Rat, Bovine, Monkey, Zebrafish

SNX1 Peptide - AC21-2076-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

Sorting nexin-1 (SNX1) (146-522, His-tag) - AR09635PU-N from Acris Antibodies Category Protein Prices $790.00 Sizes 50 µg Source E. coli Species Human

Sorting nexin-1 (SNX1) (146-522, His-tag) - AR09635PU-S from Acris Antibodies Category Protein Prices $340.00 Sizes 10 µg Source E. coli Species Human

Sorting nexin-1 (SNX1) - H00006642-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

Sorting nexin-1 (SNX1) - H00006642-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

Sorting nexin-1 (SNX1) - H00006642-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

Sorting nexin-1 (SNX1) - H00006642-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Sorting Nexin 1, Human Recombinant - 228-13153-1 from RayBiotech Category Protein Prices $118.00 Sizes 1 µg Species Human

Recombinant Human Sorting Nexin 1 - 228-13153-2 from RayBiotech Category Protein Prices $189.00 Sizes 2 µg Source Escherichia Coli. Species Human

Recombinant Human Sorting Nexin 1 - 228-13153-3 from RayBiotech Category Protein Prices $1,448.00 Sizes 3 µg Source Escherichia Coli. Species Human

SNX1, 146-522aa, Human, His tag, E.coli - 01-2164-1 from ARP American Research Products Category Protein Prices $159.00, $369.00, $849.00 Sizes 2 µg, 10 µg, 50 µg Species Human

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