| Gene Symbol | SNX1 |
|---|---|
| Entrez Gene | 6642 |
| Alt Symbol | HsT17379, VPS5 |
| Species | Human |
| Gene Type | protein-coding |
| Description | sorting nexin 1 |
| Other Description | sorting nexin 1A|sorting nexin-1 |
| Swissprots | O60750 H0Y2M5 Q13596 Q6ZRJ8 A8K6T7 O60751 A6NM19 |
| Accessions | EAW77663 EAW77664 EAW77665 EAW77666 Q13596 AB209013 BAD92250 AF065483 AAC17182 AF065484 AAC17183 AF131792 AK128179 BAC87312 AK222561 BAD96281 AK222793 BAD96513 AK291752 BAF84441 AK310618 AL050148 AU279817 BC000357 AAH00357 BQ935515 BT006983 AAP35629 BX108623 DB455188 DQ890751 ABM81677 DQ893918 ABM84844 EF491792 U53225 AAA98672 XM_005254611 XP_005254668 NM_001242933 NP_001229862 NM_003099 NP_003090 NM_148955 NP_683758 NM_152826 |
| Function | Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3- phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (PubMed:12198132). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Can sense membrane curvature and has in vitro vesicle- to-membrane remodeling activity (PubMed:19816406, PubMed:23085988). Involved in retrograde endosome-to-TGN transport of lysosomal enzyme receptors (IGF2R, M6PR and SORT1) and Shiginella dysenteria toxin stxB. Plays a role in targeting ligand-activated EGFR to the lysosomes for degradation after endoc |
| Subcellular Location | Endosome membrane {ECO:0000269|PubMed:15498486, ECO:0000269|PubMed:18088323}; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus, trans-Golgi network membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Early endosome membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, lamellipodium {ECO:0000269|PubMed:20604901}. Note=Enriched on tubular elements of the early endosome membrane. Binds preferentially to highly curved membranes enriched in phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (PubMed:15498486). Colocalized with SORT1 to tubular endosomal membrane structures called endosome-to-TGN transport carriers (ETCs) which are budding from early endosome vacuoles just before maturing into late endosome vacuoles (PubMed:18088323). Colocalizes with DNAJC13 and Shiginella dysenteria toxin stxB on early endosomes (PubMed:19874558). Colocalized with F-actin at t |
Human-SNX1-cDNA-Clone - DC00157 from Abgent, a WuXi AppTec company
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SNX1 - MBS1275849 from MyBioSource
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Human SNX1 ORF Clone(NM_001242933.1) - CDCL176569 from Creative Biomart
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human SNX1 ORF clone - CDCH084136 from Creative Biomart
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human SNX1 ORF clone - CDCH084137 from Creative Biomart
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human SNX1 ORF clone - CDCH084138 from Creative Biomart
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human SNX1 ORF clone - CDCH084139 from Creative Biomart
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human SNX1 ORF clone - CDCH084140 from Creative Biomart
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human SNX1 ORF clone - CDCH084141 from Creative Biomart
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human SNX1 ORF clone - CDCH084142 from Creative Biomart
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human SNX1 ORF clone - CDCH084143 from Creative Biomart
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human SNX1 ORF clone - CDCH084144 from Creative Biomart
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human SNX1 ORF clone - CDCH084145 from Creative Biomart
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Human SNX1 Gene ORF cDNA clone in cloning vector - HG14474-G from Sino Biological
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Human SNX1 Gene ORF cDNA clone expression plasmid, N-Flag tag - HG14474-NF from Sino Biological
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Human SNX1 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG14474-CF from Sino Biological
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Human SNX1 Gene ORF cDNA clone expression plasmid, N-Myc tag - HG14474-NM from Sino Biological
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Human SNX1 Gene ORF cDNA clone expression plasmid, N-His tag - HG14474-NH from Sino Biological
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Human SNX1 Gene ORF cDNA clone expression plasmid, C-Myc tag - HG14474-CM from Sino Biological
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Human SNX1 Gene ORF cDNA clone expression plasmid, N-GFPSpark tag - HG14474-ANG from Sino Biological
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Human SNX1 Gene ORF cDNA clone expression plasmid, N-HA tag - HG14474-NY from Sino Biological
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Human SNX1 Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG14474-ACG from Sino Biological
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Human SNX1 Gene ORF cDNA clone expression plasmid, C-His tag - HG14474-CH from Sino Biological
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Human SNX1 Gene ORF cDNA clone expression plasmid - HG14474-UT from Sino Biological
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Human SNX1 Gene ORF cDNA clone expression plasmid, C-HA tag - HG14474-CY from Sino Biological
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