SNX1

Gene Symbol	SNX1
Entrez Gene	6642
Alt Symbol	HsT17379, VPS5
Species	Human
Gene Type	protein-coding
Description	sorting nexin 1
Other Description	sorting nexin 1A|sorting nexin-1
Swissprots	O60750 H0Y2M5 Q13596 Q6ZRJ8 A8K6T7 O60751 A6NM19
Accessions	EAW77663 EAW77664 EAW77665 EAW77666 Q13596 AB209013 BAD92250 AF065483 AAC17182 AF065484 AAC17183 AF131792 AK128179 BAC87312 AK222561 BAD96281 AK222793 BAD96513 AK291752 BAF84441 AK310618 AL050148 AU279817 BC000357 AAH00357 BQ935515 BT006983 AAP35629 BX108623 DB455188 DQ890751 ABM81677 DQ893918 ABM84844 EF491792 U53225 AAA98672 XM_005254611 XP_005254668 NM_001242933 NP_001229862 NM_003099 NP_003090 NM_148955 NP_683758 NM_152826
Function	Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3- phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (PubMed:12198132). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Can sense membrane curvature and has in vitro vesicle- to-membrane remodeling activity (PubMed:19816406, PubMed:23085988). Involved in retrograde endosome-to-TGN transport of lysosomal enzyme receptors (IGF2R, M6PR and SORT1) and Shiginella dysenteria toxin stxB. Plays a role in targeting ligand-activated EGFR to the lysosomes for degradation after endoc
Subcellular Location	Endosome membrane {ECO:0000269|PubMed:15498486, ECO:0000269|PubMed:18088323}; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus, trans-Golgi network membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Early endosome membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, lamellipodium {ECO:0000269|PubMed:20604901}. Note=Enriched on tubular elements of the early endosome membrane. Binds preferentially to highly curved membranes enriched in phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (PubMed:15498486). Colocalized with SORT1 to tubular endosomal membrane structures called endosome-to-TGN transport carriers (ETCs) which are budding from early endosome vacuoles just before maturing into late endosome vacuoles (PubMed:18088323). Colocalizes with DNAJC13 and Shiginella dysenteria toxin stxB on early endosomes (PubMed:19874558). Colocalized with F-actin at t

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SNX1 (Human) IP-WB Antibody Pair - H00006642-PW1 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

SNX1 (Human) Matched Antibody Pair - H00006642-AP21 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

Sorting Nexin 1 (SNX1), ELISA Kit - MBS9304254 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 10 pg/ml. Range 62.5 pg/ml - 2000 pg/ml.

Human SNX1 ELISA Kit (Custom ELISA) - LS-F17813 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 78-5000 pg/ml

Rat SNX1 ELISA Kit (Custom ELISA) - LS-F17812 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 78-5000 pg/ml

Mouse SNX1 ELISA Kit (Custom ELISA) - LS-F17814 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 78-5000 pg/ml

Bovine SNX1 ELISA Kit (Custom ELISA) - LS-F17811 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Sensitivity To be determined Range 78-5000 pg/ml

Human Sorting nexin-1 ELISA Kit - abx251065 from Abbexa Category ELISA Kit Range 78 pg/ml - 5000 pg/ml

Human Sorting nexin-1 ELISA Kit - EKE54672 from Biomatik Category ELISA Kit Prices $809.60, $3,440.80, $6,476.80 Sizes 96 t, 5x96t, 10x96t Sensitivity The minimum detectable dose of this kit is typically less than 35 pg/ml Range 78-5000 pg/mL

SNX1 - EKH3520 from Nordic BioSite Sensitivity 46.9pg/ml Range 78-5000pg/ml

SNX1 ELISA Kit (Human) (OKEH02492) - OKEH02492 from Aviva Systems Biology Category ELISA Kit Prices $480.00 Sizes 96 wells Sensitivity < 35 pg/mL Range 78 - 5,000 pg/mL

Human SNX1 ELISA Kit - E036198 from Biobool Category ELISA Kit Sensitivity 0.1 ng/mL.

Human Sorting nexin-1 ELISA Kit - EK3641 from Signalway Antibody Category ELISA Kit Prices $739.00 Sizes 1x96t Sensitivity less than 35pg/ml Range 78-5000 pg/mL

anti-SNX1 antibody - ARG65102 from Arigo Biolaboratories Category ELISA Kit

Sorting Nexin 1 (SNX1), ELISA Kit - MBS9356571 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Sorting Nexin 1 (SNX1), ELISA Kit - MBS9350848 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Sorting Nexin 1 (SNX1), ELISA Kit - MBS9365981 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Sorting Nexin 1 (SNX1), ELISA Kit - MBS9360320 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Sorting Nexin 1 (SNX1), ELISA Kit - MBS9350830 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Sorting Nexin 1 (SNX1), ELISA Kit - MBS9361548 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Sorting Nexin 1 (SNX1), ELISA Kit - MBS9359797 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Sorting Nexin 1 (SNX1), ELISA Kit - MBS9360853 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Sorting Nexin 1 (SNX1), ELISA Kit - MBS9345555 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Sorting Nexin 1 (SNX1), ELISA Kit - MBS9352011 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Sorting Nexin 1 (SNX1), ELISA Kit - MBS9364234 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

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