| Gene Symbol |
SPO11
|
| Entrez Gene |
23626
|
| Alt Symbol |
CT35, SPATA43, TOPVIA
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
SPO11 meiotic protein covalently bound to DSB
|
| Other Description |
SPO11 meiotic protein covalently bound to DSB homolog|cancer/testis antigen 35|meiotic recombination protein SPO11|spermatogenesis associated 43
|
| Swissprots |
Q9NQM7 Q8N4V0 Q9NQM8 Q5TCI1 Q9Y5K1
|
| Accessions |
AAX44047 EAW75526 EAW75527 Q9Y5K1 AF149310 AAD44812 AF169385 AAD52562 BC033591 AAH33591 XM_005260379 XP_005260436 XM_005260380 XP_005260437 XM_005260381 XP_005260438 XM_005260382 XP_005260439 XM_011528756 XP_011527058 XM_011528757 XP_011527059 NM_012444 NP_036576 NM_198265 NP_937998
|
| Function |
Required for meiotic recombination. Mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination (By similarity). Essential for the phosphorylation of SMC3, HORMAD1 and HORMAD2 (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Nucleus {ECO:0000250}.
|
| Tissue Specificity |
Highly expressed in testis.
|
![Western Blot: SPO11 Overexpression Lysate (Adult Normal) [NBP2-07445] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for SPO11.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/9825_SPO11%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-07445-img0001.jpg)
![Western Blot: SPO11 Overexpression Lysate (Adult Normal) [NBP2-09848] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for SPO11.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/4420_SPO11%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-09848-img0001.jpg)