Gene Symbol | SPO11 |
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Entrez Gene | 23626 |
Alt Symbol | CT35, SPATA43, TOPVIA |
Species | Human |
Gene Type | protein-coding |
Description | SPO11 meiotic protein covalently bound to DSB |
Other Description | SPO11 meiotic protein covalently bound to DSB homolog|cancer/testis antigen 35|meiotic recombination protein SPO11|spermatogenesis associated 43 |
Swissprots | Q9NQM7 Q8N4V0 Q9NQM8 Q5TCI1 Q9Y5K1 |
Accessions | AAX44047 EAW75526 EAW75527 Q9Y5K1 AF149310 AAD44812 AF169385 AAD52562 BC033591 AAH33591 XM_005260379 XP_005260436 XM_005260380 XP_005260437 XM_005260381 XP_005260438 XM_005260382 XP_005260439 XM_011528756 XP_011527058 XM_011528757 XP_011527059 NM_012444 NP_036576 NM_198265 NP_937998 |
Function | Required for meiotic recombination. Mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination (By similarity). Essential for the phosphorylation of SMC3, HORMAD1 and HORMAD2 (By similarity). {ECO:0000250}. |
Subcellular Location | Nucleus {ECO:0000250}. |
Tissue Specificity | Highly expressed in testis. |
Human SPO11 cDNA clone(NM_198265.1) - CDFG012686 from Creative Biomart
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Human SPO11 cDNA clone(NM_012444.2) - CDFH018526 from Creative Biomart
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Human SPO11 ORF Clone(NM_012444.2) - CDCR296074 from Creative Biomart
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Human SPO11 ORF Clone(NM_012444.2) - CDCR296075 from Creative Biomart
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Human SPO11 ORF Clone(NM_198265.1) - CDCR325719 from Creative Biomart
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Human SPO11 ORF Clone(NM_198265.1) - CDCR325720 from Creative Biomart
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human SPO11 ORF clone - CDCH085458 from Creative Biomart
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human SPO11 ORF clone - CDCH085459 from Creative Biomart
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human SPO11 ORF clone - CDCH085460 from Creative Biomart
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human SPO11 ORF clone - CDCH085461 from Creative Biomart
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Human SPO11 ORF clone(NM_012444.2) - CDCH402198 from Creative Biomart
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Human SPO11 ORF Clone(NM_012444.2) - CDCL176898 from Creative Biomart
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Human SPO11 ORF Clone(NM_012444.2) - CDCR296074 from Creative biogene
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Human SPO11 ORF Clone(NM_198265.1) - CDCR325719 from Creative biogene
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Human SPO11 cDNA Clone(NM_198265.1) - CDFG012686 from Creative biogene
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Human SPO11 cDNA Clone(NM_012444.2) - CDFH018526 from Creative biogene
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