SPO11

Gene Symbol	SPO11
Entrez Gene	23626
Alt Symbol	CT35, SPATA43, TOPVIA
Species	Human
Gene Type	protein-coding
Description	SPO11 meiotic protein covalently bound to DSB
Other Description	SPO11 meiotic protein covalently bound to DSB homolog|cancer/testis antigen 35|meiotic recombination protein SPO11|spermatogenesis associated 43
Swissprots	Q9NQM7 Q8N4V0 Q9NQM8 Q5TCI1 Q9Y5K1
Accessions	AAX44047 EAW75526 EAW75527 Q9Y5K1 AF149310 AAD44812 AF169385 AAD52562 BC033591 AAH33591 XM_005260379 XP_005260436 XM_005260380 XP_005260437 XM_005260381 XP_005260438 XM_005260382 XP_005260439 XM_011528756 XP_011527058 XM_011528757 XP_011527059 NM_012444 NP_036576 NM_198265 NP_937998
Function	Required for meiotic recombination. Mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination (By similarity). Essential for the phosphorylation of SMC3, HORMAD1 and HORMAD2 (By similarity). {ECO:0000250}.
Subcellular Location	Nucleus {ECO:0000250}.
Tissue Specificity	Highly expressed in testis.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Spo11 CRISPR/Cas9 KO Plasmid (h) - sc-404432 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Spo11 HDR Plasmid (h) - sc-404432-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Spo11 Double Nickase Plasmid (h) - sc-404432-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Spo11 Double Nickase Plasmid (h2) - sc-404432-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Spo11 CRISPR Activation Plasmid (h) - sc-404432-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Spo11 CRISPR Activation Plasmid (h2) - sc-404432-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Spo11 Lentiviral Activation Particles (h) - sc-404432-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Spo11 Lentiviral Activation Particles (h2) - sc-404432-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Spo11 siRNA (h) - sc-38436 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Spo11 shRNA Plasmid (h) - sc-38436-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Spo11 shRNA (h) Lentiviral Particles - sc-38436-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

CompoZr® Knockout ZFN Kit - CKOZFN20500 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND20500 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR05175 from Sigma-Aldrich Category miRNA Prices $350.00 Sizes hutr05175

SPO11 siRNA (Human) - CRH8406 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

SPO11 RNAi - H00023626-R01 from Novus Biologicals Category siRNA Prices $409.00 Sizes 20 nmol Species Reactivities Human

SPO11 RNAi - H00023626-R02 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

SPO11 - MBS8220248 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human SPO11 (NM_012444.2) - SHH417004 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human SPO11(NM_012444.2) - SHL029762 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human SPO11(NM_198265.1) - SHL029844 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human SPO11(NM_012444.2) - SHL029878 from Creative biogene Category siRNA Species Reactivities Human

Human SPO11 siRNA - orb268908 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

SPO11 shRNA Plasmid (Human) - CHH8406 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

SPO11 miRNA 3'UTR clone - MiUTR1H-09855 from Creative biogene Species Reactivities Human

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