TRAF6

Gene Symbol	TRAF6
Entrez Gene	7189
Alt Symbol	MGC:3310, RNF85
Species	Human
Gene Type	protein-coding
Description	TNF receptor-associated factor 6, E3 ubiquitin protein ligase
Other Description	E3 ubiquitin-protein ligase TRAF6|RING finger protein 85|TNF receptor-associated factor 6|interleukin-1 signal transducer
Swissprots	A8KAB3 Q9Y4K3 Q8NEH5 A6NKI7 D3DR16
Accessions	AAO38054 EAW68119 EAW68120 EAW68121 EAW68122 Q9Y4K3 AK128396 AK292978 BAF85667 BC031052 AAH31052 BI463192 BQ187062 DA855021 DQ891209 ABM82135 DQ894392 ABM85318 U78798 AAB38751 NM_004620 NP_004611 NM_145803 NP_665802
Function	E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Leads to the activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c- Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to play a role in signal transduction initiated via TNF receptor, IL-1 receptor and IL-17 receptor. Regulates osteoclast differentiation by mediating the activation of adapter protein complex 1 (AP-1) and NF-kappa-B, in response to RANK-L stimulation. Together with MAP3K8, mediates CD40 signals that activate ERK in B-cells and macrophages, and thus may play a role in the regulation of immunoglobulin production. {ECO:0000269|PubMed:1105
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:18093978}. Cytoplasm, cell cortex {ECO:0000269|PubMed:18093978}. Nucleus {ECO:0000269|PubMed:18093978}. Lipid droplet {ECO:0000250}. Note=Found in the nuclei of some aggressive B-cell lymphoma cell lines as well as in the nuclei of both resting and activated T- and B-lymphocytes. Found in punctate nuclear body protein complexes. Ubiquitination may occur in the cytoplasm and sumoylation in the nucleus. RSAD2/viperin recruits it to the lipid droplet (By similarity). {ECO:0000250}.
Tissue Specificity	Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
Top Pathways	Tuberculosis, Herpes simplex infection, Measles, Pertussis, Epstein-Barr virus infection

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human TRAF6 ELISA Kit (Sandwich ELISA) - LS-F7424 from LifeSpan Bioscience Category ELISA Kit Prices $720.00 Sizes 1 plate Sensitivity 0.053 ng/ml Range 0.156-10 ng/ml

Human TRAF6 ELISA Kit (Sandwich ELISA) - LS-F12845 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.156 Range 0.156-10 ng/ml

TNF Receptor Associated Factor 6 (TRAF6), Human, ELISA Kit - SEG751Hu from ARP American Research Products Category ELISA Kit Prices $720.00 Sizes 96 t Sensitivity 0.053ng/mL Range 0.156-10ng/mL

TNF receptor-associated factor 6, TRAF6, Human, ELISA Kit - E8869h from ARP American Research Products Category ELISA Kit Prices $736.00 Sizes 96 t Range 0.156-10 ng/mL

Tumor necrosis factor receptor-associated factor 6, TRAF6, Human, ELISA Kit - CSB-E14078h from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t Sensitivity 9.75 pg/ml Range 39 pg/ml-2500 pg/ml

TRAF6 (Human) IP-WB Antibody Pair - H00007189-PW1 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

TRAF6 (Human) Matched Antibody Pair - H00007189-AP11 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

TRAF6 (Human) Matched Antibody Pair - H00007189-AP21 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

TNF Receptor Associated Factor 6 (TRAF6), ELISA Kit - MBS2022867 from MyBioSource Category ELISA Kit Prices $380.00, $565.00, $765.00, $3,130.00, $5,670.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity Typically less than 0.053ng/mL. Range 0.156-10ng/mL

TNF receptor-associated factor 6, ELISA Kit - MBS702187 from MyBioSource Category ELISA Kit Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity The minimum detectable dose of human TRAF6 is typically less than 9.75 pg/ml. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mean O.D value of 20 replicates of the zero standard added by their three standard deviations. Range 39 pg/ml -2500 pg/ml.

ELISA Kit for TNF Receptor Associated Factor 6 (TRAF6) - SEG751Hu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.053ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA’s were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

Human tumor necrosis factor receptor-associated factor 6,TRAF6 ELISA kit - CSB-E14078h from Cusabio Category ELISA Kit Sensitivity 9.8pg/ml Range 39 pg/ml-2500 pg/ml

ELISA Kit for TNF Receptor Associated Factor 6 (TRAF6) - SEG751Hu from Cloud-clone Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.053ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA's were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

Rat TRAF6 ELISA Kit (Custom ELISA) - LS-F20212 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 0.156-10 ng/ml

Pig TRAF6 ELISA Kit (Custom ELISA) - LS-F20214 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Sensitivity To be determined Range 0.156-10 ng/ml

Bovine TRAF6 ELISA Kit (Custom ELISA) - LS-F20215 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Sensitivity To be determined Range 0.156-10 ng/ml

Mouse TRAF6 ELISA Kit (Sandwich ELISA) - LS-F20213 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.156 Range 0.156-10 ng/ml

Human TNF receptor-associated factor 6 ELISA Kit - abx251764 from Abbexa Category ELISA Kit Range 0.156 ng/ml - 10 ng/ml

Human TRAF6 ELISA Kit - abx153370 from Abbexa Category ELISA Kit Sensitivity 0.053 ng/ml Range 0.156 ng/ml - 10 ng/ml

TNF Receptor Associated Factor 6 (TRAF6), Human, ELISA Kit - DL-TRAF6-Hu from ARP American Research Products Category ELISA Kit Prices $655.00 Sizes 96 t Range 0.156-10 ng/mL

Human TRAF6 ELISA Kit - abx571069 from Abbexa Category ELISA Kit Sensitivity 0.053 ng/ml Range 0.156 ng/ml - 10 ng/ml

Human TNF receptor-associated factor 6 ELISA Kit - EKE55432 from Biomatik Category ELISA Kit Prices $809.60, $3,440.80, $6,476.80 Sizes 96 t, 5x96t, 10x96t Sensitivity The minimum detectable dose of this kit is typically less than 0.078 ng/mL Range 0.156-10 ng/mL

TRAF6 - EKH4804 from Nordic BioSite Sensitivity 0.094ng/ml Range 0.156-10ng/ml

TRAF6 ELISA Kit (Human) : 96 Wells (OKEH01866) - OKEH01866 from Aviva Systems Biology Category ELISA Kit Prices $480.00 Sizes 96 wells Sensitivity < 0.078 ng/mL Range 0.156 - 10 ng/mL

Human TRAF6 ELISA Kit - E038472 from Biobool Category ELISA Kit

Search more