TRAF6

Gene Symbol	TRAF6
Entrez Gene	7189
Alt Symbol	MGC:3310, RNF85
Species	Human
Gene Type	protein-coding
Description	TNF receptor-associated factor 6, E3 ubiquitin protein ligase
Other Description	E3 ubiquitin-protein ligase TRAF6|RING finger protein 85|TNF receptor-associated factor 6|interleukin-1 signal transducer
Swissprots	A8KAB3 Q9Y4K3 Q8NEH5 A6NKI7 D3DR16
Accessions	AAO38054 EAW68119 EAW68120 EAW68121 EAW68122 Q9Y4K3 AK128396 AK292978 BAF85667 BC031052 AAH31052 BI463192 BQ187062 DA855021 DQ891209 ABM82135 DQ894392 ABM85318 U78798 AAB38751 NM_004620 NP_004611 NM_145803 NP_665802
Function	E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Leads to the activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c- Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to play a role in signal transduction initiated via TNF receptor, IL-1 receptor and IL-17 receptor. Regulates osteoclast differentiation by mediating the activation of adapter protein complex 1 (AP-1) and NF-kappa-B, in response to RANK-L stimulation. Together with MAP3K8, mediates CD40 signals that activate ERK in B-cells and macrophages, and thus may play a role in the regulation of immunoglobulin production. {ECO:0000269|PubMed:1105
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:18093978}. Cytoplasm, cell cortex {ECO:0000269|PubMed:18093978}. Nucleus {ECO:0000269|PubMed:18093978}. Lipid droplet {ECO:0000250}. Note=Found in the nuclei of some aggressive B-cell lymphoma cell lines as well as in the nuclei of both resting and activated T- and B-lymphocytes. Found in punctate nuclear body protein complexes. Ubiquitination may occur in the cytoplasm and sumoylation in the nucleus. RSAD2/viperin recruits it to the lipid droplet (By similarity). {ECO:0000250}.
Tissue Specificity	Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
Top Pathways	Tuberculosis, Herpes simplex infection, Measles, Pertussis, Epstein-Barr virus infection

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human TRAF6 full length protein - ab132023 from Abcam Category Protein Source Wheat germ Species Human

Human TRAF6 protein fragment - ab112366 from Abcam Category Protein Source Wheat germ Species Human

TRAF6 peptide - ab109643 from Abcam Category Peptide

TRAF6 peptide - ab183540 from Abcam Category Peptide

TRAF6 Antibody Blocking Peptide - LS-E10532 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

TRAF6 Antibody Blocking Peptide - LS-E6701 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

TRAF6 Antibody Blocking Peptide - LS-E30016 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

Recombinant Human TRAF-6 Protein - H00007189-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human TRAF-6 Protein - H00007189-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

TRAF-6 Blocking Peptide - NBP1-77230PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

TRAF6-AntibodyCenter-Blocking-peptide - BP19545c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Human TRAF6 protein - orb244605 from Biorbyt Category Protein Prices $213.00, $408.00, $680.00, $1,122.00, $1,777.00 Sizes 10 μg, 50 μg, 200 μg, 500 μg, 1 mg Species Human

TRAF6 Blocking Peptide - 33R-10807 from Fitzgerald Category Peptide Prices $115.00 Sizes 50 µg

TRAF6 Blocking Peptide - 33R-10288 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

Human TRAF6 Protein - abx069350 from Abbexa Category Protein Source E.coli Species Human

TRAF6 / RNF85 - H00007189-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

TRAF6 / RNF85 - H00007189-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

TRAF6 / RNF85 - H00007189-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

TRAF6 / RNF85 - H00007189-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

TRAF6 / RNF85 Control Peptide - AP09875CP-N from Acris Antibodies Category Peptide Prices $235.00 Sizes 100 µg

TRAF6 / RNF85 Control Peptide - AP30938CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

TNF Receptor Associated Factor 6 (TRAF6), Human - 20-9193 from ARP American Research Products Category Protein Prices $869.00 Sizes 50 µg Source E.coli Species Human

TRAF6 Peptide - 3129P from ProSci Category Peptide Species Human

TRAF6 fusion protein - ag14858 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

TRAF6 fusion protein - Ag24696 from Proteintech Group Category Protein Prices $199.00 Sizes 50 Source E. coli -derived, PET30a Species Human

Search more