TRAF6

Gene Symbol	TRAF6
Entrez Gene	7189
Alt Symbol	MGC:3310, RNF85
Species	Human
Gene Type	protein-coding
Description	TNF receptor-associated factor 6, E3 ubiquitin protein ligase
Other Description	E3 ubiquitin-protein ligase TRAF6|RING finger protein 85|TNF receptor-associated factor 6|interleukin-1 signal transducer
Swissprots	A8KAB3 Q9Y4K3 Q8NEH5 A6NKI7 D3DR16
Accessions	AAO38054 EAW68119 EAW68120 EAW68121 EAW68122 Q9Y4K3 AK128396 AK292978 BAF85667 BC031052 AAH31052 BI463192 BQ187062 DA855021 DQ891209 ABM82135 DQ894392 ABM85318 U78798 AAB38751 NM_004620 NP_004611 NM_145803 NP_665802
Function	E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Leads to the activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c- Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to play a role in signal transduction initiated via TNF receptor, IL-1 receptor and IL-17 receptor. Regulates osteoclast differentiation by mediating the activation of adapter protein complex 1 (AP-1) and NF-kappa-B, in response to RANK-L stimulation. Together with MAP3K8, mediates CD40 signals that activate ERK in B-cells and macrophages, and thus may play a role in the regulation of immunoglobulin production. {ECO:0000269|PubMed:1105
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:18093978}. Cytoplasm, cell cortex {ECO:0000269|PubMed:18093978}. Nucleus {ECO:0000269|PubMed:18093978}. Lipid droplet {ECO:0000250}. Note=Found in the nuclei of some aggressive B-cell lymphoma cell lines as well as in the nuclei of both resting and activated T- and B-lymphocytes. Found in punctate nuclear body protein complexes. Ubiquitination may occur in the cytoplasm and sumoylation in the nucleus. RSAD2/viperin recruits it to the lipid droplet (By similarity). {ECO:0000250}.
Tissue Specificity	Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
Top Pathways	Tuberculosis, Herpes simplex infection, Measles, Pertussis, Epstein-Barr virus infection

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

TRAF6 (D21G3) Rabbit mAb - 8028 from Cell Signaling Technology Prices $99.00, $246.00 Sizes 20 µl (2 western blots), 100 µl (10 western blots) Host Rabbit Clonality Monoclonal Clone D21G3

TRAF6 Antibody - 4743 from Cell Signaling Technology Host Rabbit Clonality Polyclonal

TRAF6 (D-10) - sc-8409 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

TRAF6 (C-16) - sc-33897 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

TRAF6 (K-16) - sc-33896 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

TRAF6 (H-274) - sc-7221 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

TRAF6 (S-20) - sc-33895 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-TRAF6 antibody - ab137452 from Abcam Prices $384.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-TRAF6 antibody - ab113244 from Abcam Prices $384.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-TRAF6 antibody - ab136019 from Abcam Prices $376.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-TRAF6 antibody - ab58369 from Abcam Prices $376.00 Sizes 50 µg Host Mouse Clonality Monoclonal

Anti-TRAF6 antibody - ab13853 from Abcam Prices $398.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-TRAF6 antibody [EP591Y] - ab33915 from Abcam Prices $400.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EP591Y

Anti-TRAF6 antibody [EP592Y] - ab40675 from Abcam Prices $378.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EP592Y

Anti-TRAF6 antibody - Carboxyterminal end - ab62488 from Abcam Prices $378.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-TRAF6 Antibody (Internal) IHC-plus™ - LS-B3379 from LifeSpan Bioscience Prices $395.00 Sizes 50 µl Host Rabbit Clonality Polyclonal

Anti-TRAF6 Antibody IHC-plus™ - LS-B4867 from LifeSpan Bioscience Prices $395.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-TRAF6 Antibody (C-Terminus) IHC-plus™ - LS-B207 from LifeSpan Bioscience Prices $395.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-TRAF6 Antibody - LS-C331172 from LifeSpan Bioscience Prices $255.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-TRAF6 Antibody IHC-plus™ - LS-B11779 from LifeSpan Bioscience Prices $395.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-TRAF6 Antibody (aa145-160) - LS-C313321 from LifeSpan Bioscience Prices $305.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-TRAF6 Antibody (C-Terminus) - LS-C10909 from LifeSpan Bioscience Prices $435.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-TRAF6 Antibody (C-Terminus) - LS-C10911 from LifeSpan Bioscience Prices $415.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-TRAF6 Antibody (aa436-449) - LS-C826 from LifeSpan Bioscience Prices $335.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-TRAF6 Antibody - LS-C146927 from LifeSpan Bioscience Prices $410.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

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