| Gene Symbol | BVES |
|---|---|
| Entrez Gene | 11149 |
| Alt Symbol | HBVES, POP1, POPDC1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | blood vessel epicardial substance |
| Other Description | popeye domain containing 1|popeye domain-containing protein 1|popeye protein 1 |
| Swissprots | E1P5D8 Q9HBV0 Q8IWC6 Q5T550 A8K1R4 Q8NE79 Q5T551 Q9UNG6 |
| Accessions | EAW48430 EAW48431 EAW48432 Q8NE79 AF204172 AAG23405 AK289979 BAF82668 BC034425 AAH34425 BC040502 AAH40502 HQ447848 ADQ32332 XM_011535398 XP_011533700 NM_001199563 NP_001186492 NM_007073 NP_009004 NM_147147 NP_671488 |
| Function | Cell adhesion molecule involved in the establishment and/or maintenance of cell integrity. Involved in the formation and regulation of the tight junction (TJ) paracellular permeability barrier in epithelial cells. Plays a role in VAMP3- mediated vesicular transport and recycling of different receptor molecules through its interaction with VAMP3. Plays a role in the regulation of cell shape and movement by modulating the Rho-family GTPase activity through its interaction with ARHGEF25/GEFT. Induces primordial adhesive contact and aggregation of epithelial cells in a Ca(2+)-independent manner. Also involved in striated muscle regeneration and repair and in the regulation of cell spreading. {ECO:0000269|PubMed:16188940}. |
| Subcellular Location | Lateral cell membrane {ECO:0000269|PubMed:16188940}. Cell junction, tight junction {ECO:0000269|PubMed:16188940}. Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Note=Colocalizes with VAMP3 at the cell-cell contact in cardiac and skeletal muscle (By similarity). Its movement from the cytoplasm to membrane is an early event occurring concurrently with cell-cell contact. Colocalizes in epithelial cells with OCLN and TJP1 in an apical-lateral position within the z axis. Detected at cell-cell contact but never observed at the free surface of epithelial cells. {ECO:0000250}. |
| Tissue Specificity | Expressed in epithelial cells (at protein level). Expressed in fetal and adult heart and skeletal muscle. {ECO:0000269|PubMed:10441744, ECO:0000269|PubMed:10882522, ECO:0000269|PubMed:16188940}. |
Blood vessel epicardial substance (BVES), Human, ELISA Kit - E01B0874 from ARP American Research Products
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Blood vessel epicardial substance (BVES), ELISA Kit - MBS7212038 from MyBioSource
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Blood vessel epicardial substance (BVES), ELISA Kit - MBS7222607 from MyBioSource
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Blood vessel epicardial substance (BVES), ELISA Kit - MBS7203948 from MyBioSource
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Blood vessel epicardial substance (BVES), ELISA Kit - MBS7215999 from MyBioSource
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Blood vessel epicardial substance (BVES), ELISA Kit - MBS7249844 from MyBioSource
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Blood vessel epicardial substance (BVES), ELISA Kit - MBS7224256 from MyBioSource
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Blood vessel epicardial substance (BVES), ELISA Kit - MBS7242698 from MyBioSource
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Blood vessel epicardial substance (BVES), ELISA Kit - MBS7225057 from MyBioSource
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Blood vessel epicardial substance (BVES), ELISA Kit - MBS7225065 from MyBioSource
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Blood vessel epicardial substance (BVES), ELISA Kit - MBS7200250 from MyBioSource
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Human BVES ELISA Kit - E005033 from Biobool
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Blood vessel epicardial substance, ELISA Kit - MBS284259 from MyBioSource
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